77286-66-9
77286-66-9
Chemical Structure
(R)-Edelfosine
Synonym(s): (R)-ET-18-OCH3
- CAS No.: 77286-66-9
- Formula:C27H58NO6P
- Molecular Weight:523.73
IUPAC Name: (R)-2-methoxy-3-(octadecyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: MHFRGQHAERHWKZ-HHHXNRCGSA-N
SMILES: CCCCCCCCCCCCCCCCCCOC[C@@H](OC)COP(OCC[N+](C)(C)C)([O-])=O
Biological Activity: (R)-Edelfosine ((R)-ET-18-OCH3) is a membrane-active ether lipid analog with anti-HIV and antitumor activities. (R)-Edelfosine induces membrane perturbation by forming interdigitated bilayers and inserting into membranes. (R)-Edelfosine can be used in research related to cancer and HIV[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(R)-Edelfosine | 99.9% | (R)-Edelfosine ((R)-ET-18-OCH3) is a membrane-active ether lipid analog with anti-HIV and antitumor activities. (R)-Edelfosine induces membrane perturbation by forming interdigitated bilayers and inserting into membranes. (R)-Edelfosine can be used in research related to cancer and HIV. | ||||||||||||||||||||
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(R)-Edelfosine (Standard) | ≥98% | (R)-Edelfosine (Standard) ((R)-ET-18-OCH3 (Standard)) is the analytical standard of (R)-Edelfosine (HY-108610). This product is intended for research and analytical applications. (R)-Edelfosine ((R)-ET-18-OCH3) is a membrane-active ether lipid analog with anti-HIV and antitumor activities. (R)-Edelfosine induces membrane perturbation by forming interdigitated bilayers and inserting into membranes. (R)-Edelfosine can be used in research related to cancer and HIV. | ||||||||||||||||||||
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Edelfosine | 99.9% | Edelfosine (ET-18-OCH3) is an orally active lipid raft modulator and apoptosis inducer that alters membrane fluidity and preferentially inserts into tumor cell membranes. Edelfosine recruits death receptor ligands (FasL/CD95L, TRAIL) and Bid to lipid rafts to form death-inducing signaling complexes, thereby initiating mitochondria-dependent apoptosis and inducing cytochrome c release. Edelfosine also exerts anti-inflammatory effects, promotes L-Selectin shedding, and causes no gastrointestinal or organ toxicity. In addition, Edelfosine inhibits nucleic acid and protein synthesis in Leishmania donovani and exhibits antiproliferative activity. Edelfosine can be used in research on multiple myeloma, inflammatory bowel diseases (such as ulcerative colitis and Crohn's disease), and visceral leishmaniasis. | ||||||||||||||||||||
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(S)-Edelfosine | 99.90% | (S)-Edelfosine ((S)-ET-18-OCH3) is the (S)-enantiomer of Edelfosine (ET-18-OCH3) (HY-108610C). Edelfosine is a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 Death receptor. | ||||||||||||||||||||
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C16-PAF | 99.90% | C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability. | ||||||||||||||||||||
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1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine | 1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine ((Rac)-PAF (C16)) is an endogenous inflammatory lipid mediator. 1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine acts as a high-affinity agonist for PAFR (GPCR), inducing platelet aggregation, vascular permeability, and leukocyte chemotaxis at extremely low concentrations. 1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine exerts its effects via cell surface receptors to regulate inflammation. | |||||||||||||||||||||
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PAF (C18) | 99.89% | C18-PAF, octadecane PAF, is the ligand of platelet-activating factor and PAF G protein-coupled receptor (PAFR). C18-PAF has renovasodilator properties and antihypertensive lipid properties. C18-PAF increases renal blood flow and causes dose-dependent systemic hypotension. | ||||||||||||||||||||
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2-O-Methyl PAF C-16 | 2-O-Methyl PAF C-16 (ET-18-O-OCH3), a structural analog of the mediator of inflammation platelet-activating factor (PAF), is a cytotoxic ether lipid. 2-O-Methyl PAF C-16 stimulates TNF-α release in murine macrophages. | |||||||||||||||||||||
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2-O-Ethyl PAF C-16 | 99.9% | 2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC50 of 21 nM. | ||||||||||||||||||||
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Lyso-PAF C-18 | 99.74% | Lyso-PAF C-18 is a single-chain ether phospholipid with membrane regulatory activity, and Lyso-PAF is the deacetylated inactive precursor of PAF. Lyso-PAF C-18 regulates the activity of plasma membrane Ca2+-ATPase, and its mechanism of action may involve altering the lipid microenvironment of this enzyme. Lyso-PAF C-18 activates the calcium ATPase in rat synaptosomal membranes and inhibits the calcium ATPase in rat leukocyte membranes. Lyso-PAF C-18 can be used in cell membrane-related research. | ||||||||||||||||||||
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1-O-Palmityl-2-O-methyl-rac-glycero-3-phosphocholine | 1-O-Palmityl-2-O-methyl-rac-glycero-3-phosphocholine is a synthetic phospholipid analogue with activity in studying lipid interactions and membrane asymmetry. 1-O-Palmityl-2-O-methyl-rac-glycero-3-phosphocholine is used to explore the overall stability of lipid bilayers. 1-O-Palmityl-2-O-methyl-rac-glycero-3-phosphocholine is of great significance for the study of membrane structure and function. | |||||||||||||||||||||
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C17 Lyso PAF | C17 Lyso PAF (1-O-Heptadecyl-2-hydroxy-sn-glycero-3-phosphocholine) is a precursor and metabolite of 1-O-heptadecyl-2-acetyl-sn-glycero-3-phosphocholine (C17:0 PAF). | |||||||||||||||||||||
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