1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. C16-PAF

C16-PAF (Synonyms: PAF (C16))

Cat. No.: HY-108635 Purity: >98.0%
Handling Instructions

C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF induces increased vascular permeability.

For research use only. We do not sell to patients.

C16-PAF Chemical Structure

C16-PAF Chemical Structure

CAS No. : 74389-68-7

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Based on 1 publication(s) in Google Scholar

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Description

C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF induces increased vascular permeability[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

C16-PAF (PAF (C16); 0.5-1.5 μM; for 24 hours) elicits significant concentration-dependent neuronal loss in PAFR−/− but not PAFR+/+ cultures. C16-PAF (1 μM) elicits neuronal death in PAFR−/− cells infected with EGFP alone[1].
C16-PAF (1 μM; for 24 hours) activates caspase 7 but not caspase 3 in PAFR−/− neurons[1].
C16-PAF is synthesized by two distinct pathways; the remodeling pathway and the de novo synthesis pathway. C16-PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor[2][3].
C16-PAF (1-25 μg/ml; 6, 12, 24 h) inhibits M. smegmatis and M. bovis BCG growth in a time-dependent manner[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Cerebellar granule neurons (CGNs) from PAFR−/− and PAFR+/+ mice
Concentration: 0.5-1.5 μM
Incubation Time: 24 hours
Result: Elicited significant concentration-dependent neuronal loss in PAFR−/− but not PAFR+/+ cultures in serum-free media.

Western Blot Analysis[1]

Cell Line: CGNs
Concentration: 1 μM
Incubation Time: 24 hours
Result: Activated caspase 7 but not caspase 3 in PAFR−/− neurons.
Molecular Weight

523.68

Formula

C₂₆H₅₄NO₇P

CAS No.

74389-68-7

SMILES

CCCCCCCCCCCCCCCCOC[[email protected]@H](OC(C)=O)COP(OCC[N+](C)(C)C)([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: >98.0%

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Keywords:

C16-PAFPAF (C16)Endogenous Metabolitephospholipidmediatorplatelet-activatingfactorPAFPAFRapoptoticvascularpermeabilityInhibitorinhibitorinhibit

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C16-PAF
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