Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata

  • J Nat Prod. 2001 Apr;64(4):533-5. doi: 10.1021/np0005210.
N Alam  1 ,  B H Bae ,  J Hong ,  C O Lee ,  B A Shin ,  K S Im ,  J H Jung
Affiliations
  • 1. College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
PMID: 11325244 DOI: 10.1021/np0005210
Abstract

A known (1) and four new (2--5) lyso-PAF (platelet activating factor) derivatives were isolated from the Sponge Spirastrella abata. Two of them are unprecedented in having a methoxy group at C-2'. The structures have been determined by combined spectroscopic methods. Their inhibitory effect on the biosynthesis of Cholesterol and cytotoxicity against human solid tumor cell lines are reported.