ER 50891
Based on 1 Customer Validation
ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.59%
- CAS. Nr.: 187400-85-7
- Formel: C29H24N2O2
- Molecular Weight:432.51
-
Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
Metabolism/Protease Compound Library
HY-L012
-
Transcription Factor-Targeted Library
HY-L090
-
Protein-protein Interaction Inhibitor Library
HY-L109
-
Nuclear Receptor Compound Library
HY-L126
-
Osteogenesis Compound Library
HY-L131
-
Heterocyclic Compound Library
HY-L138
-
Metabolic Enzyme Compound Library
HY-L146
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
Biologische Aktivität
|
RXR α |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
6.4 nM
Compound: 12f
|
Antagonistic activity was evaluated in terms of inhibition of HL-60 cell differentiation activity by ATRA (10 nM)
Antagonistic activity was evaluated in terms of inhibition of HL-60 cell differentiation activity by ATRA (10 nM)
|
[PMID: 11354380] |
ER 50891 (1-3 μM, 3 days) significantly promotes total cell metabolic activity of MC3T3-E1 preosteoblasts alone and antagonizes the inhibitory effect of ATRA on total cell metabolic activity[1].
ER 50891 (0.25-3 μM, 3 days) dose-dependently relieves the inhibition of 1 μM ATRA on OCN expression in MC3T3-E1 preosteoblasts[1].
ER 50891 (1.5-3 μM, 19 days) rescues the extracellular matrix mineralization of MC3T3-E1 preosteoblasts inhibited by ATRA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 187400-85-7
-
Appearance Solid
-
Molecular Weight 432.51
-
Formel C29H24N2O2
-
Color Light yellow to yellow
-
SMILES
O=C(O)C1=CC=C(C2=CC=C(C3=NC4=C(C(C)C)C=CC=C4C(C5=CC=CC=C5)=C3)N2)C=C1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reinheit & Dokumentation
-
Data Sheet (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ER 50891 Related Classifications
HY-108531 Related Classifications
Powered by Bioz