187400-85-7
Chemical Structure
ER 50891
- CAS No.: 187400-85-7
- Formula:C29H24N2O2
- Molecular Weight:432.51
IUPAC Name: 4-(5-(8-isopropyl-4-phenylquinolin-2-yl)-1H-pyrrol-2-yl)benzoic acid
InChIKey: LSGNKLDHMQVTEK-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(C2=CC=C(C3=NC4=C(C(C)C)C=CC=C4C(C5=CC=CC=C5)=C3)N2)C=C1
Biological Activity: ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis[1].
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ER 50891 | 98.59% | ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis. | ||||||||||||||||||||
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Keywords
