L-670596
L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069.
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- CAS No.: 121083-05-4
- Formule: C22H21F2NO4S
- Masse moléculaire:433.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
L-670596 inhibits the aggregation of human platelet rich plasma induced by U-44069[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
L-670596 (2 mg/kg; i.v.; single) inhibits platelet aggregation to collagen in pigs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Guinea pig (arachidonic acid and U-44069 induced bronchoconstriction model)[1].
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Dosage:0.03mg/kg
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Administration:Intravenous injection; single.
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Result:Inhibited arachidonic acid and U-44069 induced bronchoconstriction.
Chemical Information
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CAS No. 121083-05-4
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Masse moléculaire 433.47
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Formule C22H21F2NO4S
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SMILES
O=C(O)CC1C(N(CC2=CC=C(S(=O)(C)=O)C=C2)C3=C4C=C(F)C=C3F)=C4CCC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Ford-Hutchinson AW, et al. The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. Can J Physiol Pharmacol. 1989 Sep;67(9):989-93. [Content Brief]
[2]. Nuttall GA, et al. Protamine-heparin-induced pulmonary hypertension in pigs: effects of treatment with a thromboxane receptor antagonist on hemodynamics and coagulation. Anesthesiology. 1991 Jan;74(1):138-45. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-670596 Related Classifications
HY-108561 Related Classifications
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