1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. PF-04418948

PF-04418948 

Cat. No.: HY-18966 Purity: 99.22%
Handling Instructions

PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM.

For research use only. We do not sell to patients.

PF-04418948 Chemical Structure

PF-04418948 Chemical Structure

CAS No. : 1078166-57-0

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 440 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE PF-04418948

    PF-04418948 purchased from MCE. Usage Cited in: J Virol. 2018 Sep 26;92(20):e01018-18.

    A549 cells are added with an EP2 or an EP4 inhibitor. After 48 h, cells are subjected to WB with an anti-Axl antibody.
    • Biological Activity

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    • References

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    Description

    PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM.

    Clinical Trial
    Molecular Weight

    409.41

    Formula

    C₂₃H₂₀FNO₅

    CAS No.

    1078166-57-0

    SMILES

    O=C(C1(COC2=CC=C3C=C(OC)C=CC3=C2)CN(C(C4=CC=C(F)C=C4)=O)C1)O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (244.25 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4425 mL 12.2127 mL 24.4254 mL
    5 mM 0.4885 mL 2.4425 mL 4.8851 mL
    10 mM 0.2443 mL 1.2213 mL 2.4425 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    • Molarity Calculator

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    × = ×
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    Keywords:

    PF-04418948PF04418948PF 04418948Prostaglandin ReceptorInhibitorinhibitorinhibit

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    Product Name:
    PF-04418948
    Cat. No.:
    HY-18966
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