1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Sulprostone

Sulprostone (Synonyms: SHB 286; CP-34089; ZK-57671)

Cat. No.: HY-19360
Handling Instructions

Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery.

For research use only. We do not sell to patients.

Sulprostone Chemical Structure

Sulprostone Chemical Structure

CAS No. : 60325-46-4

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Description

Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery[1][2][3].

IC50 & Target

EP3 Receptor

 

In Vitro

Sulprostone (SHB 286) has Ki values of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells[1].
Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sulprostone (SHB 286; 0.5 mg/kg; IV) has a T1/2 of 0.451 hours, a CL of 56 mL/min•kg, a Vss of 0.583 L/kg and an AUC of 149 ng•h/mL[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male cynomolgus monkey[3]
Dosage: 0.5 mg/kg (Pharmacokinetic Analysis)
Administration: IV
Result: Had a T1/2 of 0.451 hours, a CL of 56 mL/min•kg, a Vss of 0.583 L/kg and an AUC of 149 ng•h/mL.
Clinical Trial
Molecular Weight

465.56

Formula

C₂₃H₃₁NO₇S

CAS No.

60325-46-4

SMILES

O=C(NS(=O)(C)=O)CCC/C=C\C[[email protected]@H]1[[email protected]@H](/C=C/[[email protected]@H](O)COC2=CC=CC=C2)[[email protected]](O)CC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SulprostoneSHB 286 CP-34089 ZK-57671SHB286SHB-286CP34089CP 34089CP-34089ZK57671ZK 57671ZK-57671Prostaglandin ReceptorprostaglandinE2PGE2antiulcernonsteroidalabortifacientpregnancyterminationhemorrhagesInhibitorinhibitorinhibit

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