1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Sulprostone

Sulprostone  (Synonyms: SHB 286; CP-34089; ZK-57671)

Cat. No.: HY-19360 Purity: ≥99.0%
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Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery.

For research use only. We do not sell to patients.

Sulprostone Chemical Structure

Sulprostone Chemical Structure

CAS No. : 60325-46-4

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500 μg USD 220 In-stock
Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Description

Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery[1][2][3].

In Vitro

Sulprostone (SHB 286) has Ki values of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells[1].
Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sulprostone (SHB 286; 0.5 mg/kg; IV) has a T1/2 of 0.451 hours, a CL of 56 mL/min•kg, a Vss of 0.583 L/kg and an AUC of 149 ng•h/mL[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male cynomolgus monkey[3]
Dosage: 0.5 mg/kg (Pharmacokinetic Analysis)
Administration: IV
Result: Had a T1/2 of 0.451 hours, a CL of 56 mL/min•kg, a Vss of 0.583 L/kg and an AUC of 149 ng•h/mL.
Clinical Trial
Molecular Weight

465.56

Formula

C23H31NO7S

CAS No.
SMILES

O=C(NS(=O)(C)=O)CCC/C=C\C[[email protected]@H]1[[email protected]@H](/C=C/[[email protected]@H](O)COC2=CC=CC=C2)[[email protected]](O)CC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: ≥99.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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