1. GPCR/G Protein
  2. Prostaglandin Receptor

Iloprost (Synonyms: Ciloprost; ZK 36374)

Cat. No.: HY-A0096 Purity: 99.83%
Data Sheet SDS Handling Instructions

Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2.

For research use only. We do not sell to patients.
Iloprost Chemical Structure

Iloprost Chemical Structure

CAS No. : 78919-13-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $278 In-stock
1 mg $90 In-stock
2 mg $150 In-stock
5 mg $350 In-stock
10 mg $550 In-stock
25 mg $950 In-stock
50 mg $1600 In-stock
100 mg $2600 In-stock
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2. Target: Iloprost is a stable prostacyclin analog commonly employed in the treatment of peripheral vascular disease and also indicated in the treatment of patients affected by systemic sclerosis (SSc) in the presence of severe Raynaud's phenomenon (RP). [1] Iloprost dilates systemic and pulmonary arterial vascularbeds. Iloprost also affects platelet aggregation but the relevance of this effect to the treatment of pulmonary hypertension is unknown. The two diastereoisomers of iloprost differ in their potency in dilating blood vessels, with the 4S isomer substantially more potent than the 4R isomer.[2] Iloprost is a stable carbacyclin derivative of prostacyclin, was studied during electrically-induced coronary artery thrombosis in the open chest anesthetized pig. Infusion of ZK 36374 (100 ng/kg/min, n = 6) had no effect on heart rate and cardiac output, but caused a 20% reduction in mean arterial blood pressure by peripheral vasodilation. In animals receiving solvent or no drug prior to thrombosis induction, the time to occlusive coronary artery thrombosis (TOT) was 30 +/- 2 minutes (mean +/- SEM, n = 17). Pretreatment with an i.v. infusion of ZK 36374 (100 ng/kg/min) prolonged TOT by 50% to 47 +/- 7 minutes (p less than 0.005, n = 6). This prolongation of TOT was not due to the lower blood pressure in the ZK 36374 group, as dihydralazine in a dose that lowered arterial blood pressure to the same extent had no effect on TOT (32 +/- 4 minutes, n = 4). The results indicate that ZK 36374 may be useful in delaying (or preventing) occlusive coronary artery thrombi. [3]

Clinical Trial
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References
Molecular Weight

360.49

Formula

C₂₂H₃₂O₄

CAS No.

78919-13-8

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Iloprost
Cat. No.:
HY-A0096
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