2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Prostaglandin Receptor Endogenous Metabolite
  4. Iloprost

Iloprost  (Synonyms: Ciloprost; ZK 36374)

Cat. No.: HY-A0096 Purity: 99.76%
COA Handling Instructions

Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research.

For research use only. We do not sell to patients.

Iloprost Chemical Structure

Iloprost Chemical Structure

CAS No. : 78919-13-8

Size Price Stock Quantity
Oil + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 748 In-stock
Solution
10 mM * 1 mL in DMSO USD 748 In-stock
Oil
2 mg USD 340 In-stock
5 mg USD 680 In-stock
10 mg USD 1100 In-stock
25 mg USD 2250 In-stock
50 mg USD 3500 In-stock
100 mg USD 5600 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Iloprost:

Iloprost Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research[1][2][3][4].

In Vitro

Prostacyclin (PGI2) is synthesised in oviductal fluid and enhance the embryo development[1].
Iloprost is an PGI2 analog, and affects maturation and developmental competence of bovine oocytes[1].
Iloprost (0.5 μM; 22-24 h) increases blastocyst rates of bovine embryos as well as proportion of expanded blastocysts[1].
Iloprost (0.5 μM; 22-24 h) assists maturation rates and cumulus cell expansion of bovine oocytes, and increases the mRNA expression of genes related to cumulus expansion[1].
Iloprost (0.5 μM; 22-24 h) reduces the occurrence of apoptosis in COCs and promotes an anti-apoptotic balance in the transcription of genes involved in apoptosis (BAX and BCL2) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Iloprost Related Antibodies

RT-PCR[1]

Cell Line: Bovine oocytes: cumulus oocyte complexes (COCs)
Concentration: 0.5 μM
Incubation Time: 22-24 hours
Result: Increased mRNA expression levels of cysteine proteinases cathepsins, including ADAM17, AREG, and TNFAIP6 23 and cathepsin genes (CTSK and CTSS).
In Vivo

Iloprost (0.3 mg/kg/min; via s.c. mini pumps; 33 d) has a significant anti-metastatic activity in a spontaneously metastasizing tumor model in rat[2].
Iloprost (0.2 mg/kg/d; i.p.; 10 d) attenuates hyperoxia effects and reduces inflammation in the newborn mouse lung, with Cyclooxygenase-2 (COX-2/PTGS2) mediates hyperoxia-induced impairment[3].
Iloprost (0.2 mg/kg; i.v. or i.p.) exhibits short half-life, and is often administered by means of frequent (every 2-4h) inhalation in treatment[4].
Comparison of pharmacokinetic parameter in rats and mice[4]

Animal Route Dose (mg/kg) AUC (ng•h/mL) F (%) CL (range) (mL/min/kg) t1/2λi (min) t1/2λz (min)
Mice i.v. 0.2 21.9 100 152 3 15
Rat i.g. 0.2 2.2 10 / 4 58

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spontaneously metastasizing R 3327 MAT Lu prostate carcinoma in Cop rat[2]
Dosage: 0.3 mg/kg/min
Administration: Subcutaneous administration via Alzet mini pumps; continuously for 33 days
Result: Reduced the number of visible lung metastases, but had no effect on the growth of the primary tumor.
This action was based on the ability to reduce the attachment of tumor cells to platelets and to inhibit adhesion of tumor cells-platelet aggregates to the endothelial lining.
Animal Model: Newborn C57BL/6 mice (4-day-old)[3]
Dosage: 0.2 mg/kg
Administration: Intraperitoneal injection; once daily; 10 days
Result: Reduced markedly pro-inflammatory cytokines IL-1β and TNF-α mRNA and protein.
Inhibited alveolar septation, reduced hyperoxia-induced total lung resistance and myeloperoxidase, prevented hyperoxia-reduced lung microvascular density.
Clinical Trial
Molecular Weight

360.49

Appearance

Oil

Formula

C22H32O4
CAS No.
SMILES

O=C(O)CCC/C=C1C[C@@]2([H])C[C@@H](O)[C@H](/C=C/[C@@H](O)C(C)CC#CC)[C@@]2([H])C\1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (277.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7740 mL 13.8700 mL 27.7400 mL
5 mM 0.5548 mL 2.7740 mL 5.5480 mL
10 mM 0.2774 mL 1.3870 mL 2.7740 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.76%

COA (246 KB) HNMR (284 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References
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Iloprost Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Iloprost78919-13-8Ciloprost ZK 36374ZK36374ZK 36374ZK-36374Prostaglandin ReceptorEndogenous MetabolitePGI2 analogin vitro maturationIVMembryo developmentanti-inflammationperipheral vascular diseasesanti-metastatictumor cell-platelet interactionin vitro fertilizationCyclooxygenase-2COX-2/PTGS2hyperoxia-induced impairmentInhibitorinhibitorinhibit

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