1. Anti-infection
    Apoptosis
    Autophagy
  2. HIV
    Reverse Transcriptase
    Autophagy
    Apoptosis
  3. Stavudine

Stavudine (Synonyms: d4T)

Cat. No.: HY-B0116 Purity: 99.12%
Handling Instructions

Stavudine is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

For research use only. We do not sell to patients.

Stavudine Chemical Structure

Stavudine Chemical Structure

CAS No. : 3056-17-5

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Stavudine is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Target: HIV RT; NRTIs Stavudine is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Stavudine is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it [1]. Mice were treated for 2 weeks with stavudine d4T (500 mg/kg/day), L-carnitine (200 mg/kg/day) or both drugs concomitantly. Body fatness was assessed by dual energy X-ray absorptiometry, and investigations were performed in plasma, liver, muscle and WAT. D4T reduced the gain of body adiposity, WAT leptin, whole body FAO and plasma ketone bodies, and increased liver triglycerides and plasma aminotransferases with mild ultrastructural abnormalities in hepatocytes [2]. Clinical indications: HIV-1 infection FDA Approved Date: June 24, 1994 Toxicity: peripheral neuropathy; lipodystrophy

Clinical Trial
Molecular Weight

224.21

Formula

C₁₀H₁₂N₂O₄

CAS No.

3056-17-5

SMILES

OC[[email protected]]1O[[email protected]@H](N2C=C(C)C(NC2=O)=O)C=C1

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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 47 mg/mL (209.62 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4601 mL 22.3005 mL 44.6010 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL
10 mM 0.4460 mL 2.2301 mL 4.4601 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Stavudined4THIVReverse TranscriptaseAutophagyApoptosisHuman immunodeficiency virusInhibitorinhibitorinhibit

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