Stavudine sodium (Synonyms: d4T sodium)

Name: Stavudine sodium
Brand: MedChemExpress
SKU: HY-B0116A
Rating: 5.0 (4 reviews)

Cat. No.: HY-B0116A Purity: 99.40%: Data Sheet
COA
Handling Instructions
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Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis.

For research use only. We do not sell to patients.

Stavudine sodium Chemical Structure

CAS No. : 134624-73-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Stavudine sodium:

Stavudine In-stock

4 Publications Citing Use of MCE Stavudine sodium

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NLRP3 NLRP1 NOD1 NOD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

HIV-1

HIV-2

NLRP3

In Vitro

Stavudine (d4T) sodium (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages^[3].
Stavudine (d4T) sodium (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages^[3].
Stavudine (d4T) sodium (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Stavudine (d4T) sodium (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male RjOrl Swiss mice weighing 0.028-0.03 kg^[1]
Dosage:	500 mg/kg
Administration:	Daily liquid; 2 weeks
Result:	Reduced fat weight gain by 58%, 5.7 g in the control group and 4.9 g in the d4T treated group. Significantly elevated plasma ALT and LDH levels. Reduced plasma acetoacetic acid and beta-hydroxybutyric acid levels. Reduced liver and muscle mtDNA levels at high dose concentration of 500 mg/kg.

Clinical Trial

Molecular Weight

246.20

Formula

C₁₀H₁₁N₂NaO₄

CAS No.

134624-73-0

Appearance

Solid

SMILES

[O-]C[C@H]1O[C@@H](N2C=C(C)C(NC2=O)=O)C=C1.[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (203.09 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0617 mL	20.3087 mL	40.6174 mL
5 mM	0.8123 mL	4.0617 mL	8.1235 mL
10 mM	0.4062 mL	2.0309 mL	4.0617 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.40%

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COA (254 KB)

Handling Instructions (2659 KB)

References

[1]. Moyle GJ, et al. The role of stavudine in the management of adults with HIV infection. Antivir Ther. 1997;2(4):207-218. [Content Brief]

[2]. Riddler SA, et al. Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T). Antiviral Res. 1995;27(3):189-203. [Content Brief]

[3]. La Rosa F, et al. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. J Alzheimers Dis. 2019;72(2):401-412. [Content Brief]

[4]. Ferraresi R, et al. Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs. FEBS Lett. 2006;580(28-29):6612-6616. [Content Brief]

[5]. Anissa Igoudjil, et al. High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice. Antivir Ther. 2007;12(3):389-400. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.0617 mL	20.3087 mL	40.6174 mL	101.5435 mL
	5 mM	0.8123 mL	4.0617 mL	8.1235 mL	20.3087 mL
	10 mM	0.4062 mL	2.0309 mL	4.0617 mL	10.1543 mL
	15 mM	0.2708 mL	1.3539 mL	2.7078 mL	6.7696 mL
	20 mM	0.2031 mL	1.0154 mL	2.0309 mL	5.0772 mL
	25 mM	0.1625 mL	0.8123 mL	1.6247 mL	4.0617 mL
	30 mM	0.1354 mL	0.6770 mL	1.3539 mL	3.3848 mL
	40 mM	0.1015 mL	0.5077 mL	1.0154 mL	2.5386 mL
	50 mM	0.0812 mL	0.4062 mL	0.8123 mL	2.0309 mL
	60 mM	0.0677 mL	0.3385 mL	0.6770 mL	1.6924 mL
	80 mM	0.0508 mL	0.2539 mL	0.5077 mL	1.2693 mL
	100 mM	0.0406 mL	0.2031 mL	0.4062 mL	1.0154 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Stavudine sodium Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stavudine134624-73-0d4TReverse TranscriptaseHIVNucleoside Antimetabolite/AnalogNOD-like Receptor (NLR)AutophagyApoptosisHuman immunodeficiency virusantiretroviralnucleosideanaloguemtDNAinflammasomeAmyloid-βInhibitorinhibitorinhibit

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Stavudine sodium (Synonyms: d4T sodium)

Customer Review

Other Forms of Stavudine sodium:

Stavudine sodium Related Antibodies

4 Publications Citing Use of MCE Stavudine sodium

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All HIV Isoform Specific Products:

View All NOD-like Receptor (NLR) Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Stavudine sodium Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Stavudine sodium Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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