Cat. No.: HY-B0116A

Stavudine sodium

(Synonyms: d4T sodium)

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine sodium induces apoptosis.

For research use only. We do not sell to patients.

Purity: 99.40%
CAS No.: 134624-73-0
Formula: C₁₀H₁₁N₂NaO₄
Molecular Weight:246.20

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Stavudine sodium Chemical Structure

CAS No.: 134624-73-0

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

HIV-1

HIV-2

NLRP3

All HIV Isoforms :

All NOD-like Receptor (NLR) Isoforms :

In Vitro

Stavudine (d4T) sodium (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages^[3].
Stavudine (d4T) sodium (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages^[3].
Stavudine (d4T) sodium (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Stavudine (d4T) sodium (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male RjOrl Swiss mice weighing 0.028-0.03 kg^[1]
Dosage:

500 mg/kg
Administration:

Daily liquid; 2 weeks
Result:

Reduced fat weight gain by 58%, 5.7 g in the control group and 4.9 g in the d4T treated group.
Significantly elevated plasma ALT and LDH levels.
Reduced plasma acetoacetic acid and beta-hydroxybutyric acid levels.
Reduced liver and muscle mtDNA levels at high dose concentration of 500 mg/kg.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 134624-73-0
Appearance Solid
Molecular Weight 246.20
Formula C₁₀H₁₁N₂NaO₄
Color White to off-white
SMILES

[O-]C[C@H]1O[C@@H](N2C=C(C)C(NC2=O)=O)C=C1.[Na+]
Synonyms

d4T sodium
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

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Toxicology

Stavudine exposure results in developmental abnormalities by causing DNA damage, inhibiting cell proliferation and inducing apoptosis in mouse embryos. [Abstract]

2020 Jun;439:152443. PMID: 32278789
Int J Antimicrob Agents

Efficacy of antiretroviral compounds against Toxoplasma gondii in vitro. [Abstract]

2019 Dec;54(6):814-819. PMID: 31479744
ACS Infect Dis

Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights. [Abstract]

2025 Oct 30. PMID: 41166549
Biotechnol Bioeng

An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury. [Abstract]

2021 Dec;118(12):4687-4698. PMID: 34478150

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (203.09 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.0617 mL

20.3087 mL

40.6174 mL

5 mM

0.8123 mL

4.0617 mL

8.1235 mL

10 mM

0.4062 mL

2.0309 mL

4.0617 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Moyle GJ, et al. The role of stavudine in the management of adults with HIV infection. Antivir Ther. 1997;2(4):207-218. [Content Brief]

[2]. Riddler SA, et al. Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T). Antiviral Res. 1995;27(3):189-203. [Content Brief]

[3]. La Rosa F, et al. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. J Alzheimers Dis. 2019;72(2):401-412. [Content Brief]

[4]. Ferraresi R, et al. Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs. FEBS Lett. 2006;580(28-29):6612-6616. [Content Brief]

[5]. Anissa Igoudjil, et al. High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice. Antivir Ther. 2007;12(3):389-400. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	4.0617 mL	20.3087 mL	40.6174 mL	101.5435 mL
	5 mM	0.8123 mL	4.0617 mL	8.1235 mL	20.3087 mL
	10 mM	0.4062 mL	2.0309 mL	4.0617 mL	10.1543 mL
	15 mM	0.2708 mL	1.3539 mL	2.7078 mL	6.7696 mL
	20 mM	0.2031 mL	1.0154 mL	2.0309 mL	5.0772 mL
	25 mM	0.1625 mL	0.8123 mL	1.6247 mL	4.0617 mL
	30 mM	0.1354 mL	0.6770 mL	1.3539 mL	3.3848 mL
	40 mM	0.1015 mL	0.5077 mL	1.0154 mL	2.5386 mL
	50 mM	0.0812 mL	0.4062 mL	0.8123 mL	2.0309 mL
	60 mM	0.0677 mL	0.3385 mL	0.6770 mL	1.6924 mL
	80 mM	0.0508 mL	0.2539 mL	0.5077 mL	1.2693 mL
	100 mM	0.0406 mL	0.2031 mL	0.4062 mL	1.0154 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Stavudine sodium

4 Cited Publications

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Stavudine sodium

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Publications Citing Use of MedChemExpress (MCE) Stavudine sodium

All HIV Isoforms

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Chemical Information

Publications (4)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Stavudine sodium Related Classifications

HY-B0116A Related Classifications