1. GPCR/G Protein
  2. Prostaglandin Receptor

GW627368 

Cat. No.: HY-16963 Purity: 99.88%
Data Sheet SDS Handling Instructions

GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).

For research use only. We do not sell to patients.
GW627368 Chemical Structure

GW627368 Chemical Structure

CAS No. : 439288-66-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 273 In-stock
1 mg USD 60 In-stock
5 mg USD 228 In-stock
10 mg USD 420 In-stock
25 mg USD 840 In-stock
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM). IC50 value: Target: EP4 antagonist in vitro: At recombinant human prostanoid EP4 receptors expressed in HEK293 cells, GW627368X produced parallel rightward shifts of PGE2 concentration-effect (E/[A]) curves resulting in an affinity (pKb) estimate of 7.9 +/- 0.4. GW627368X appears to bind to human prostanoid TP receptors but not the TP receptors of other species. In human washed platelets, GW627368X (10 microM) produced 100% inhibition of U-46619 (EC100)-induced aggregation (approximate pA2 approximately 7.0) [1]. in vivo: Oral administration of GW627368X showed significant tumor regression characterized by tumor reduction and induction of apoptosis. Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma [2].

References
Molecular Weight

544.62

Formula

C₃₀H₂₈N₂O₆S

CAS No.

439288-66-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
GW627368
Cat. No.:
HY-16963
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