1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. GW627368

GW627368 

Cat. No.: HY-16963 Purity: 99.97%
Handling Instructions

GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively.

For research use only. We do not sell to patients.

GW627368 Chemical Structure

GW627368 Chemical Structure

CAS No. : 439288-66-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 72 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
25 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products

    GW627368 purchased from MCE. Usage Cited in: Oncol Lett. 2018 Jan;15(1):552-558.

    The level of PD 1 expression is subsequently detected by western blot analysis. Data is presented as the mean±standard deviation. P<0.05. The control group is treated with PGE2, but not with an antagonist.

    GW627368 purchased from MCE. Usage Cited in: J Cell Physiol. 2018 Nov;233(11):8984-8995.

    Small white follicles (SWFs) are treated with TG6-10-1 or GW627368 and WB are used and gray analysis of PCNA, CDK2, and CCND1.
    • Biological Activity

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    Description

    GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively[1].

    IC50 & Target

    pKi :7.0 (hEP4), 6.8 (hTP)[1]

    In Vitro

    GW627368 (GW627368X) appears to bind to human prostanoid TP receptors but not the TP receptors of other species[1].
    GW627368 (GW627368X) (10 μM) produces 100% inhibition of U-46619 (EC100)-induced aggregation (approximate pA2 approximately 7.0) in human washed platelets[1].
    GW627368 (GW627368X) is devoid of agonist activity and actually produced a significant and concentration-related reduction in basal cAMP levels with pIC50 value of 6.3[1].
    GW627368 (GW627368X) induces inhibition of proliferation and invasion of human SUM149 IBC tumor cells beginning at 0.1 μM, with inhibition of proliferation and invasion of MDA-MB-231 non-IBC cells at higher concentrations[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    GW627368 (GW627368X) (0-15 mg/kg; p.o.; every alternate day for 28 days) shows significant tumor regression characterized by tumor reduction and induction of apoptosis[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 6-8 weeks Swiss albino mice[3]
    Dosage: 0 mg/kg, 5 mg/kg, 10 mg/kg, 15 mg/kg, 15 mg/kg
    Administration: Oral administration, every alternate day for 28 days
    Result: Displayed anti-tumor and anti-proliferative potential in sarcoma 180 bearing mice.
    Molecular Weight

    544.62

    Formula

    C₃₀H₂₈N₂O₆S

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (183.61 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8361 mL 9.1807 mL 18.3614 mL
    5 mM 0.3672 mL 1.8361 mL 3.6723 mL
    10 mM 0.1836 mL 0.9181 mL 1.8361 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Product Name:
    GW627368
    Cat. No.:
    HY-16963
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