1. GPCR/G Protein
  2. Prostaglandin Receptor

GW627368 

Cat. No.: HY-16963 Purity: 99.88%
Handling Instructions

GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).

For research use only. We do not sell to patients.

GW627368 Chemical Structure

GW627368 Chemical Structure

CAS No. : 439288-66-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 273 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 228 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
25 mg USD 840 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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    GW627368 purchased from MCE. Usage Cited in: Oncol Lett. 2018 Jan;15(1):552-558.

    The level of PD 1 expression is subsequently detected by western blot analysis. Data is presented as the mean±standard deviation. P<0.05. The control group is treated with PGE2, but not with an antagonist.

    GW627368 purchased from MCE. Usage Cited in: J Cell Physiol. 2018 Jun 19.

    Small white follicles (SWFs) are treated with TG6-10-1 or GW627368 and WB are used and gray analysis of PCNA, CDK2, and CCND1.
    • Biological Activity

    • Technical Information

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    • References

    Description

    GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM). IC50 value: Target: EP4 antagonist in vitro: At recombinant human prostanoid EP4 receptors expressed in HEK293 cells, GW627368X produced parallel rightward shifts of PGE2 concentration-effect (E/[A]) curves resulting in an affinity (pKb) estimate of 7.9 +/- 0.4. GW627368X appears to bind to human prostanoid TP receptors but not the TP receptors of other species. In human washed platelets, GW627368X (10 microM) produced 100% inhibition of U-46619 (EC100)-induced aggregation (approximate pA2 approximately 7.0) [1]. in vivo: Oral administration of GW627368X showed significant tumor regression characterized by tumor reduction and induction of apoptosis. Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma [2].

    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8361 mL 9.1807 mL 18.3614 mL
    5 mM 0.3672 mL 1.8361 mL 3.6723 mL
    10 mM 0.1836 mL 0.9181 mL 1.8361 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    544.62

    Formula

    C₃₀H₂₈N₂O₆S

    CAS No.

    439288-66-1

    SMILES

    O=C(NS(=O)(C1=CC=CC=C1)=O)CC2=CC=C(N(CC3=C4C(OCC)=C(C=CC=C5)C5=C3OCC)C4=O)C=C2

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

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    × = ×
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    Product Name:
    GW627368
    Cat. No.:
    HY-16963
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    GW627368

    Cat. No.: HY-16963