16,16-Dimethyl prostaglandin E2  (Synonyms: 16,16-dimethyl PGE2)

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway^[1][2].

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2; 10 μg/kg; i.p.; every 12 hours; for 8 days) rescues the exacerbated DSS colitis phenotype of Tpl2^IMF-KO mice and restores epithelial proliferation and structure^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

380.52

C₂₂H₃₆O₅

39746-25-3

Liquid

Colorless to light yellow

CCCCC(C)([C@@H](/C=C/[C@@H]1[C@@H](C/C=C\CCCC(O)=O)C(C[C@H]1O)=O)O)C

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Hagedorn EJ, et al. Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. xp Cell Res. 2014 Dec 10;329(2):220-6.  [Content Brief]

  [2]. Roulis M, et al. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4658-67.  [Content Brief]