16,16-Dimethyl prostaglandin E2
Based on 1 Customer Validation
16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway.
For research use only. We do not sell to patients.
- Purity: 99.02%
- CAS No.: 39746-25-3
- Formula: C22H36O5
- Molecular Weight:380.52
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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EP2 |
EP4 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tpl2IMF-KO mice[2]
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Dosage:10 µg/kg
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Administration:IP; every 12 hours; for 8 days
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Result:Rescued the exacerbated DSS colitis phenotype and restores epithelial proliferation and structure.
Chemical Information
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CAS No. 39746-25-3
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Appearance Liquid
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Molecular Weight 380.52
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Formula C22H36O5
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Color Colorless to light yellow
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SMILES
CCCCC(C)([C@@H](/C=C/[C@@H]1[C@@H](C/C=C\CCCC(O)=O)C(C[C@H]1O)=O)O)C
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Synonyms
16,16-dimethyl PGE2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (273 KB)
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SDS (604 KB)
- English - EN (604 KB)
- Français - FR (604 KB)
- Deutsch - DE (604 KB)
- Norwegian - NO (604 KB)
- Español - ES (604 KB)
- Swedish - SV (604 KB)
- Italian - IT (604 KB)
- Korean - KR (604 KB)
- Portuguese - PT (604 KB)
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Handling Instructions (2659 KB)
References
[1]. Hagedorn EJ, et al. Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. xp Cell Res. 2014 Dec 10;329(2):220-6. [Content Brief]
[2]. Roulis M, et al. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4658-67. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
16,16-Dimethyl prostaglandin E2 Related Classifications
HY-106420 Related Classifications
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