1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. 16,16-Dimethyl prostaglandin E2

16,16-Dimethyl prostaglandin E2  (Synonyms: 16,16-dimethyl PGE2)

Cat. No.: HY-106420
COA Handling Instructions

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway.

For research use only. We do not sell to patients.

16,16-Dimethyl prostaglandin E2 Chemical Structure

16,16-Dimethyl prostaglandin E2 Chemical Structure

CAS No. : 39746-25-3

Size Price Stock Quantity
Solution
5 mg (26.28 mM * 500 μL in Methyl acetate) USD 320 In-stock
Estimated Time of Arrival: December 31
Solution
10 mg (26.28 mM * 1 mL in Methyl acetate) USD 510 In-stock
Estimated Time of Arrival: December 31
Solution
25 mg (26.28 mM * 2.5 mL in Methyl acetate) USD 1050 In-stock
Estimated Time of Arrival: December 31
Solution
50 mg (26.28 mM * 5 mL in Methyl acetate) USD 1680 In-stock
Estimated Time of Arrival: December 31
Solution
100 mg (26.28 mM * 10 mL in Methyl acetate) USD 2650 In-stock
Estimated Time of Arrival: December 31

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway[1][2].

In Vivo

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2; 10 µg/kg; i.p.; every 12 hours; for 8 days) rescues the exacerbated DSS colitis phenotype of Tpl2IMF-KO mice and restores epithelial proliferation and structure[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tpl2IMF-KO mice[2]
Dosage: 10 µg/kg
Administration: IP; every 12 hours; for 8 days
Result: Rescued the exacerbated DSS colitis phenotype and restores epithelial proliferation and structure.
Molecular Weight

380.52

Formula

C22H36O5

CAS No.
SMILES

CCCCC(C)([[email protected]@H](/C=C/[[email protected]@H]1[[email protected]@H](C/C=C\CCCC(O)=O)C(C[[email protected]]1O)=O)O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (262.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6280 mL 13.1399 mL 26.2798 mL
5 mM 0.5256 mL 2.6280 mL 5.2560 mL
10 mM 0.2628 mL 1.3140 mL 2.6280 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
16,16-Dimethyl prostaglandin E2
Cat. No.:
HY-106420
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