1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. 16,16-Dimethyl prostaglandin E2

16,16-Dimethyl prostaglandin E2 (Synonyms: 16,16-dimethyl PGE2)

Cat. No.: HY-106420
Handling Instructions

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway.

For research use only. We do not sell to patients.

16,16-Dimethyl prostaglandin E2 Chemical Structure

16,16-Dimethyl prostaglandin E2 Chemical Structure

CAS No. : 39746-25-3

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Description

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway[1][2].

IC50 & Target

EP2

 

EP4

 

In Vivo

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2; 10 µg/kg; i.p.; every 12 hours; for 8 days) rescues the exacerbated DSS colitis phenotype of Tpl2IMF-KO mice and restores epithelial proliferation and structure[2].

Animal Model: Tpl2IMF-KO mice[2]
Dosage: 10 µg/kg
Administration: IP; every 12 hours; for 8 days
Result: Rescued the exacerbated DSS colitis phenotype and restores epithelial proliferation and structure.
Molecular Weight

380.52

Formula

C₂₂H₃₆O₅

CAS No.

39746-25-3

SMILES

CCCCC(C)([[email protected]@H](/C=C/[[email protected]@H]1[[email protected]@H](C/C=C\CCCC(O)=O)C(C[[email protected]]1O)=O)O)C

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Keywords:

16,16-Dimethyl prostaglandin E216,16-dimethyl PGE2Prostaglandin ReceptorOrallyHematopoieticstemcellsHSCshomeostasisregulatorInhibitorinhibitorinhibit

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16,16-Dimethyl prostaglandin E2
Cat. No.:
HY-106420
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