39746-25-3
Chemical Structure
16,16-Dimethyl prostaglandin E2
Synonym(s): 16,16-dimethyl PGE2
- CAS No.: 39746-25-3
- Formula:C22H36O5
- Molecular Weight:380.52
IUPAC Name: (Z)-7-((1R,2R,3R)-3-hydroxy-2-((R,E)-3-hydroxy-4,4-dimethyloct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid
InChIKey: QAOBBBBDJSWHMU-WMBBNPMCSA-N
SMILES: CCCCC(C)([C@@H](/C=C/[C@@H]1[C@@H](C/C=C\CCCC(O)=O)C(C[C@H]1O)=O)O)C
Biological Activity:
16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway[1][2].
The product specifications provided below refer solely to the active content of 16,16-Dimethyl prostaglandin E2.
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16,16-Dimethyl prostaglandin E2 | 99.02% | 16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway. The product specifications provided below refer solely to the active content of 16,16-Dimethyl prostaglandin E2. |
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Similarity Score 0.85
HY-16508016,16-Dimethyl prostaglandin D2 -
Similarity Score 0.84
HY-106077Meteneprost -
Similarity Score 0.83
HY-101952Prostaglandin E2 -
Similarity Score 0.83
HY-118465ent-Prostaglandin E2 -
Similarity Score 0.83
HY-13022311β-Prostaglandin E2 -
Similarity Score 0.83
HY-1303048-Isoprostaglandin E2 -
Similarity Score 0.83
HY-13069415(R)-Prostaglandin E2 -
Similarity Score 0.83
HY-1350235-trans-PGE2 -
Similarity Score 0.83
HY-11475116,16-Dimethylprostaglandin E1 -
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References
- [1]. Hagedorn EJ, et al. Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. xp Cell Res. 2014 Dec 10;329(2):220-6. [Content Brief]
- [2]. Roulis M, et al. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4658-67. [Content Brief]
