TCS 2510  (Synonyms: CAY10598)

TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases^[1].

EP4^[1]

TCS 2510 (0.001~100 μM; GLUTag cells) stimulates glucagon like peptide 1 secretion. TCS2510 activates the Gas signaling pathway. TCS 2510 (10 μM; 2~24 h; GLUTag cells) increases the Gcg mRNA expression levels. TCS 2510 produces a concentration dependent increase in cAMP levels in GLUTag cells with EC₅₀ of 20 nM and the maximal stimulation of 60 % over the basal cAMP levels. The decrease in cell impedance in GLUTag cells observed with TCS 2510 is concentration dependent with IC₅₀ of 15 nM. TCS 2510 produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TCS 2510 (0.1~10 mg/kg; p.o.) produces a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration^[1].
TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels^[1].
TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levels^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

383.49

C₂₁H₂₉N₅O₂

346673-06-1

Liquid

Colorless to light yellow

O=C1N(CCCCCCC2=NNN=N2)[C@@H](/C=C/[C@@H](O)CC3=CC=CC=C3)CC1

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Coskun T, et al. Activation of prostaglandin E receptor 4 triggers secretion of gut hormone peptides GLP-1, GLP-2, and PYY. Endocrinology. 2013;154(1):45-53.  [Content Brief]