1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. TCS 2510

TCS 2510 (Synonyms: CAY10598)

Cat. No.: HY-108557
Handling Instructions

TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.

For research use only. We do not sell to patients.

TCS 2510 Chemical Structure

TCS 2510 Chemical Structure

CAS No. : 346673-06-1

Size Stock
500 μg Get quote

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases[1].

IC50 & Target[1]

EP4

 

In Vitro

TCS 2510 (0.001~100 μM; GLUTag cells) stimulates glucagon like peptide 1 secretion. TCS2510 activates the Gas signaling pathway. TCS 2510 (10 μM; 2~24 h; GLUTag cells) increases the Gcg mRNA expression levels. TCS 2510 produces a concentration dependent increase in cAMP levels in GLUTag cells with EC50 of 20 nM and the maximal stimulation of 60 % over the basal cAMP levels. The decrease in cell impedance in GLUTag cells observed with TCS 2510 is concentration dependent with IC50 of 15 nM. TCS 2510 produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TCS 2510 (0.1~10 mg/kg; p.o.) produces a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration[1].
TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels[1].
TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levels[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 0.1~10 mg/kg
Administration: P.o.
Result: Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.
Animal Model: Mice[1]
Dosage: 10 mg/kg
Administration: P.o.
Result: Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.
Animal Model: Mice[1]
Dosage: 1~10 mg/kg
Administration: P.o.
Result: Afforded a significant elevation in plasma glucagon like peptide 2 levels.
Molecular Weight

383.49

Formula

C₂₁H₂₉N₅O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TCS 2510
Cat. No.:
HY-108557
Quantity:
MCE Japan Authorized Agent: