121083-05-4
Chemical Structure
L-670596
- CAS No.: 121083-05-4
- Formula:C22H21F2NO4S
- Molecular Weight:433.47
IUPAC Name: 2-(6,8-difluoro-9-(4-(methylsulfonyl)benzyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
InChIKey: GMJWAIMJHBTYPD-UHFFFAOYSA-N
SMILES: O=C(O)CC1C(N(CC2=CC=C(S(=O)(C)=O)C=C2)C3=C4C=C(F)C=C3F)=C4CCC1
Biological Activity: L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069[1][2].
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L-670596 | L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069. | |||||||||||||||||||||
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- [1]. Ford-Hutchinson AW, et al. The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. Can J Physiol Pharmacol. 1989 Sep;67(9):989-93. [Content Brief]
- [2]. Nuttall GA, et al. Protamine-heparin-induced pulmonary hypertension in pigs: effects of treatment with a thromboxane receptor antagonist on hemodynamics and coagulation. Anesthesiology. 1991 Jan;74(1):138-45. [Content Brief]
Keywords
