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Cat. No.: HY-139093

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Paracetamol-cysteine

Name: Paracetamol-cysteine
Brand: MedChemExpress
SKU: HY-139093
Availability: PreOrder

(Synonyms: APAP-Cys)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Paracetamol-cysteine (APAP-Cys) is a cysteine adduct of Acetaminophen (HY-66005). It forms when Acetaminophen is oxidized to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI).

For research use only. We do not sell to patients.

CAS No.: 53446-10-9
Formula: C₁₁H₁₄N₂O₄S
Molecular Weight:270.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Paracetamol-cysteine Chemical Structure

CAS No.: 53446-10-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (2)
Purity & Documentation
References
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Bioz

Biological Activity

Description

Paracetamol-cysteine (APAP-Cys) is a cysteine adduct of Acetaminophen (HY-66005). It forms when Acetaminophen is oxidized to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI)^[1]^[2].

In Vitro

Paracetamol-cysteine is an exogenous-endogenous conjugate metabolite formed after drug exposure.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 53446-10-9
Molecular Weight 270.30
Formula C₁₁H₁₄N₂O₄S
Synonyms

APAP-Cys
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Bioorg Chem

4-Methyl-5-Acetylthiazole (Q11), a novel CYP2E1 inhibitor, has a protective effect on the hepatotoxicity induced by acetaminophen. [Abstract]

2026 Mar:170:109492. PMID: 41547040
Drug Metab Dispos

Synergistic hepatotoxicity of azithromycin and acetaminophen involves liver X receptor α-mediated metabolic dysregulation and endoplasmic reticulum stress. [Abstract]

2026 May 13. PMID: 42263432

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Frey SM, et al. Confirming the Causative Role of Acetaminophen in Indeterminate Acute Liver Failure Using Acetaminophen-Cysteine Adducts. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2015 Jun;11(2):218-22.

[2]. Heard K, et al. Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing. Br J Clin Pharmacol. 2016 Mar;81(3):562-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Paracetamol-cysteine

2 Cited Publications

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (2)
Purity & Documentation
References

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Paracetamol-cysteine

Publications Citing Use of MedChemExpress (MCE) Paracetamol-cysteine