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Cat. No.: HY-139093A

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Paracetamol-cysteine TFA

Name: Paracetamol-cysteine TFA
Brand: MedChemExpress
SKU: HY-139093A
Price: 180.00 USD
Availability: InStock
Rating: 5 (2 reviews)

(Synonyms: APAP-Cys TFA)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Paracetamol-cysteine TFA (APAP-Cys TFA) is a cysteine adduct of Acetaminophen (HY-66005). It forms when Acetaminophen is oxidized to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI).

For research use only. We do not sell to patients.

Purity: 99.9%
CAS No.: 1331891-93-0
Formula: C₁₃H₁₅F₃N₂O₆S
Molecular Weight:384.33

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Paracetamol-cysteine TFA Chemical Structure

CAS No.: 1331891-93-0

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
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Biological Activity

Description

Paracetamol-cysteine TFA (APAP-Cys TFA) is a cysteine adduct of Acetaminophen (HY-66005). It forms when Acetaminophen is oxidized to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI)^[1]^[2].

In Vitro

Paracetamol-cysteine TFA is an exogenous-endogenous conjugate metabolite formed after drug exposure.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1331891-93-0
Appearance Solid
Molecular Weight 384.33
Formula C₁₃H₁₅F₃N₂O₆S
Color Off-white to gray
SMILES

N[C@@H](CSC1=CC(NC(C)=O)=CC=C1O)C(O)=O.OC(C(F)(F)F)=O
Synonyms

APAP-Cys TFA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (2)

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Bioorg Chem

4-Methyl-5-Acetylthiazole (Q11), a novel CYP2E1 inhibitor, has a protective effect on the hepatotoxicity induced by acetaminophen. [Abstract]

2026 Mar:170:109492. PMID: 41547040
Drug Metab Dispos

Synergistic hepatotoxicity of azithromycin and acetaminophen involves liver X receptor α-mediated metabolic dysregulation and endoplasmic reticulum stress. [Abstract]

2026 May 13. PMID: 42263432

Solvent & Solubility

In Vitro:

DMSO : 0.17 mg/mL (0.44 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Frey SM, et al. Confirming the Causative Role of Acetaminophen in Indeterminate Acute Liver Failure Using Acetaminophen-Cysteine Adducts. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2015 Jun;11(2):218-22.

[2]. Heard K, et al. Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing. Br J Clin Pharmacol. 2016 Mar;81(3):562-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Paracetamol-cysteine TFA

2 Cited Publications

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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Paracetamol-cysteine TFA

Publications Citing Use of MedChemExpress (MCE) Paracetamol-cysteine TFA