53446-10-9
53446-10-9
Chemical Structure
Paracetamol-cysteine
Synonym(s): APAP-Cys
- CAS No.: 53446-10-9
- Formula:C11H14N2O4S
- Molecular Weight:270.30
IUPAC Name: S-(5-acetamido-2-hydroxyphenyl)-L-cysteine
InChIKey: LLHICPSCVFRWDT-QMMMGPOBSA-N
SMILES: N[C@@H](CSC1=CC(NC(C)=O)=CC=C1O)C(O)=O
Biological Activity: Paracetamol-cysteine (APAP-Cys) is a cysteine adduct of Acetaminophen (HY-66005). It forms when Acetaminophen is oxidized to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI)[1][2].
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Paracetamol-cysteine | Paracetamol-cysteine (APAP-Cys) is a cysteine adduct of Acetaminophen (HY-66005). It forms when Acetaminophen is oxidized to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI). | |||||||||||||||||||||
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References
- [1]. Frey SM, et al. Confirming the Causative Role of Acetaminophen in Indeterminate Acute Liver Failure Using Acetaminophen-Cysteine Adducts. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2015 Jun;11(2):218-22.
- [2]. Heard K, et al. Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing. Br J Clin Pharmacol. 2016 Mar;81(3):562-8. [Content Brief]
