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Orlistat

(Synonyms: Tetrahydrolipstatin; Ro-18-0647)
32 Cited Publications
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Based on 32 publication(s) in Google Scholar

Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity. Anti-atherosclerotic effect.

For research use only. We do not sell to patients.

  • Purity: 99.94%
  • CAS No.: 96829-58-2
  • Formula: C29H53NO5
  • Molecular Weight:495.73
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Orlistat Chemical Structure
  • Experimental Validation Results for Orlistat
  • Experimental Validation Results for Orlistat
  • Experimental Validation Results for Orlistat
  • Experimental Validation Results for Orlistat
  • Experimental Validation Results for Orlistat
  • Experimental Validation Results for Orlistat
  • Orlistat Chemical Structure
    Orlistat Chemical Structure
  • Experimental Validation Results for Orlistat
  • Experimental Validation Results for Orlistat
  • Experimental Validation Results for Orlistat
  • Experimental Validation Results for Orlistat
  • Experimental Validation Results for Orlistat
  • Experimental Validation Results for Orlistat
CAS No.: 96829-58-2
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  • Orlistat Chemical Structure
    Orlistat Chemical Structure
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    Orlistat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 19;16(1):1762. [Abstract]

    Customer Validation
     Inhibition of FASN by Orlistat (50-100μM) reduced the protein levels of mutp53, but not wtp53, in different cells. Cells were treated with the small-molecule FASN inhibitor orlistat at the indicated concentrations for 24 h and then subjected to Western blot analysis.

  • 1/16

    Orlistat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 19;16(1):1762. [Abstract]

    Customer Validation
     Orlistat displayed a more pronounced inhibitory effect on AIG in p53R248W/- HCT116 and E1A/Ras-transformed p53R172H/R172H MEF cells compared with their corresponding p53+/+ or p53-/- cells. Cells were treated with or without Orlistat (50 or 100 µM) for 72 h for AIG assays.

  • 1/16

    Orlistat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jul 26;15(1):6311. [Abstract]

    Customer Validation
     HEp-2 cells were either mock-infected or infected with RSV (MOI = 1) in the presence or absence of Orlistat (10 μM) for the indicated durations. The activity of LAL in HEp-2 cells 24 h after RSV infection was determined using flow cytometry (n = 3 independent experiments).

  • 1/16

    Orlistat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jul 26;15(1):6311. [Abstract]

    Customer Validation
     HEp-2 cells were either mock-infected or infected with RSV (MOI = 1) in the presence or absence of Orlistat (10 μM) for the indicated durations. The mRNA level of LAL gene in HEp-2 cells 12 h or 24 h after RSV infection was determined using RT-PCR (n = 3 independent experiments).

  • 1/16

    Orlistat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jul 26;15(1):6311. [Abstract]

    Customer Validation
     HEp-2 cells were either mock-infected or infected with RSV (MOI = 1) in the presence or absence of Orlistat (10 μM) for the indicated durations. Western blotting analysis of LAL in HEp-2 cells 12 h or 24 h after RSV infection (n = 3 independent experiments).

  • 1/16

    Orlistat purchased from MedChemExpress. Usage Cited in: Nutrients. 2018 Mar 15;10(3). pii: E353. [Abstract]

    Customer Validation
     Treatment with Orlistat (20-40 μM) leads to increased phospho-ACC without affecting the phosphorylation status of TOPK/survivin.

  • Orlistat