96829-58-2
96829-58-2
Chemical Structure
Orlistat
Synonym(s): Tetrahydrolipstatin; Ro-18-0647
- CAS No.: 96829-58-2
- Formula:C29H53NO5
- Molecular Weight:495.73
IUPAC Name: (S)-1-((2S,3S)-3-hexyl-4-oxooxetan-2-yl)tridecan-2-yl formyl-L-leucinate
InChIKey: AHLBNYSZXLDEJQ-FWEHEUNISA-N
SMILES: O=C1[C@@H](CCCCCC)[C@H](C[C@@H](OC([C@@H](N([H])C([H])=O)CC(C)C)=O)CCCCCCCCCCC)O1
Biological Activity: Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity[1]. Anti-atherosclerotic effect[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Orlistat | 99.94% | Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity. Anti-atherosclerotic effect. | ||||||||||||||||||||
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Orlistat (Standard) | 98.21% | Orlistat (Standard) is the analytical standard of Orlistat. This product is intended for research and analytical applications. Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity. Anti-atherosclerotic effect. | ||||||||||||||||||||
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Orlistat-d3 | Orlistat-d3 is a deuterated labeled Orlistat. Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity.?Anti-atherosclerotic?effect. | |||||||||||||||||||||
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L-Isoleucine orlistat | L-Isoleucine orlistat is a tetrahydrostatin analog and a selective inhibitor of diacylglycerol lipase α (DAGLα), with IC50 < 50 nM. L-Isoleucine orlistat has potential for research on neural signaling and inflammation-related diseases. | |||||||||||||||||||||
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OMDM169 | OMDM169 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor with activity to increase 2-AG levels. OMDM169 exerts analgesic activity through indirect activation of cannabinoid receptors. The effective concentration of OMDM169 is 0.13 μM. | |||||||||||||||||||||
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Valilactone | 98.2% | Valilactone is a potent and effective inhibitor of esterase, produced by actinomycetes. | ||||||||||||||||||||
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α/β-Hydrolase-IN-1 | α/β-Hydrolase-IN-1 exhibits the best-in-class MICs of 50 μM (25 μg/mL) and 16 μM (8.4 μg/mL) against M. smegmatis and M. tuberculosis H37Ra, respectively. | |||||||||||||||||||||
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(R,S,S,S)-Orlistat | (R,S,S,S)-Orlistat is a stereogenic derivative of orlistat (tetrahydrolipstatin; THL) (HY-B0218). (R,S,S,S)-Orlistat inhibits three Mycobacterium tuberculosis lipid esterases, Ag85C (KI: 16.43 μM), Rv3802 (EC50: 16.2 nM), and Pks13-TE. | |||||||||||||||||||||
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Panclicin A | Panclicin A is a potent pancreatic lipase inhibitor. | |||||||||||||||||||||
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Panclicin B | Panclicin B is a potent pancreatic lipase inhibitor. | |||||||||||||||||||||
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Panclicin D | Panclicin D is a potent pancreatic lipase inhibitor. | |||||||||||||||||||||
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Panclicin E | Panclicin E is a potent pancreatic lipase inhibitor. | |||||||||||||||||||||
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References
- [1]. Giorgia Cioccoloni, et al. Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro. Int J Oncol. 2015 Aug;47(2):764-72. [Content Brief]
- [2]. Zaidatul Akmal Othman, et al. Anti-Atherogenic Effects of Orlistat on Obesity-Induced Vascular Oxidative Stress Rat Model. Antioxidants (Basel). 2021 Feb 6;10(2):251. [Content Brief]
