2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. ALOX15-IN-1

ALOX15-IN-1 (compound 8b) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 0.04 and 2.06 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively.

For research use only. We do not sell to patients.

ALOX15-IN-1 Chemical Structure

ALOX15-IN-1 Chemical Structure

CAS No. : 2764818-24-6

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5 mg USD 220 In-stock
10 mg USD 360 In-stock
25 mg USD 720 In-stock
50 mg USD 1150 In-stock
100 mg USD 1850 In-stock
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Based on 1 publication(s) in Google Scholar

ALOX15-IN-1 Related Antibodies

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Description

ALOX15-IN-1 (compound 8b) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 0.04 and 2.06 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1].

Molecular Weight

473.59

Formula

C24H31N3O5S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(NC1=C(C=CC(C2=CC3=C(C=CC=C3)N2)=C1)OC)(NC(OCCCCCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (211.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1115 mL 10.5577 mL 21.1153 mL
5 mM 0.4223 mL 2.1115 mL 4.2231 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1115 mL 10.5577 mL 21.1153 mL 52.7883 mL
5 mM 0.4223 mL 2.1115 mL 4.2231 mL 10.5577 mL
10 mM 0.2112 mL 1.0558 mL 2.1115 mL 5.2788 mL
15 mM 0.1408 mL 0.7038 mL 1.4077 mL 3.5192 mL
20 mM 0.1056 mL 0.5279 mL 1.0558 mL 2.6394 mL
25 mM 0.0845 mL 0.4223 mL 0.8446 mL 2.1115 mL
30 mM 0.0704 mL 0.3519 mL 0.7038 mL 1.7596 mL
40 mM 0.0528 mL 0.2639 mL 0.5279 mL 1.3197 mL
50 mM 0.0422 mL 0.2112 mL 0.4223 mL 1.0558 mL
60 mM 0.0352 mL 0.1760 mL 0.3519 mL 0.8798 mL
80 mM 0.0264 mL 0.1320 mL 0.2639 mL 0.6599 mL
100 mM 0.0211 mL 0.1056 mL 0.2112 mL 0.5279 mL
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ALOX15-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALOX15-IN-12764818-24-6LipoxygenaseLOXALOX15 0rthologslinoleic acidarachidonic acidInhibitorinhibitorinhibit

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