L-Cystine dihydrochloride

Name: L-Cystine dihydrochloride
Brand: MedChemExpress
SKU: HY-W009203
Rating: 4.5 (1 reviews)

Cat. No.: HY-W009203 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Cystine dihydrochloride can be used as a cell culture component and is a sulfur-containing precursor of glutathione (GSH) synthesis. L-Cystine dihydrochloride homeostasis is also important for GSH functions.

For research use only. We do not sell to patients.

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L-Cystine dihydrochloride Chemical Structure

CAS No. : 30925-07-6

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

313.22

Formula

C₆H₁₄Cl₂N₂O₄S₂

CAS No.

30925-07-6

Appearance

Solid

Color

White to off-white

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (159.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1926 mL	15.9632 mL	31.9264 mL
5 mM	0.6385 mL	3.1926 mL	6.3853 mL
10 mM	0.3193 mL	1.5963 mL	3.1926 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (3.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (270 KB) SDS (476 KB)

COA (247 KB) HNMR (130 KB)

Handling Instructions (2659 KB)

References

[1]. Pader I, et al. Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase. Proc Natl Acad Sci U S A. 2014 May 13;111(19):6964-9. [Content Brief]

[2]. Xiaojun Lian. Serum-free human pluripotent stem cell culture medium. Patent WO2021094826 A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1926 mL	15.9632 mL	31.9264 mL	79.8161 mL
	5 mM	0.6385 mL	3.1926 mL	6.3853 mL	15.9632 mL
	10 mM	0.3193 mL	1.5963 mL	3.1926 mL	7.9816 mL
	15 mM	0.2128 mL	1.0642 mL	2.1284 mL	5.3211 mL
	20 mM	0.1596 mL	0.7982 mL	1.5963 mL	3.9908 mL
	25 mM	0.1277 mL	0.6385 mL	1.2771 mL	3.1926 mL
	30 mM	0.1064 mL	0.5321 mL	1.0642 mL	2.6605 mL
	40 mM	0.0798 mL	0.3991 mL	0.7982 mL	1.9954 mL
	50 mM	0.0639 mL	0.3193 mL	0.6385 mL	1.5963 mL
	60 mM	0.0532 mL	0.2661 mL	0.5321 mL	1.3303 mL
	80 mM	0.0399 mL	0.1995 mL	0.3991 mL	0.9977 mL
	100 mM	0.0319 mL	0.1596 mL	0.3193 mL	0.7982 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Cystine30925-07-6OthersglutathioneGSHcell culture componentInhibitorinhibitorinhibit

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L-Cystine dihydrochloride

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