2. Cell Cycle/DNA Damage Cytoskeleton Antibody-drug Conjugate/ADC Related
  3. Microtubule/Tubulin ADC Cytotoxin
  4. Fmoc-MMAE

Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC.

For research use only. We do not sell to patients.

Fmoc-MMAE Chemical Structure

Fmoc-MMAE Chemical Structure

CAS No. : 474645-26-6

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Based on 1 publication(s) in Google Scholar

Fmoc-MMAE Related Antibodies

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Description

Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC[1].

IC50 & Target[1]

Auristatin

 

Molecular Weight

940.22

Formula

C54H77N5O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3C4=C(C=CC=C4)C5=C3C=CC=C5)=O)C)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 45 mg/mL (47.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0636 mL 5.3179 mL 10.6358 mL
5 mM 0.2127 mL 1.0636 mL 2.1272 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0636 mL 5.3179 mL 10.6358 mL 26.5895 mL
5 mM 0.2127 mL 1.0636 mL 2.1272 mL 5.3179 mL
10 mM 0.1064 mL 0.5318 mL 1.0636 mL 2.6590 mL
15 mM 0.0709 mL 0.3545 mL 0.7091 mL 1.7726 mL
20 mM 0.0532 mL 0.2659 mL 0.5318 mL 1.3295 mL
25 mM 0.0425 mL 0.2127 mL 0.4254 mL 1.0636 mL
30 mM 0.0355 mL 0.1773 mL 0.3545 mL 0.8863 mL
40 mM 0.0266 mL 0.1329 mL 0.2659 mL 0.6647 mL
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Fmoc-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-MMAE474645-26-6Microtubule/TubulinADC CytotoxinADC PayloadFmocprotectedgroupaminoacidInhibitorinhibitorinhibit

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