1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. TrxR

TrxR

Thioredoxin Reductase

TrxR (Thioredoxin Reductase) is a selenium-containing pyridine nucleotide-disulphide oxidoreductase. There are three isoforms of mammalian TrxRs: TrxR1 (TXRND1), TrxR2 (TXNRD2) and TrxR3 (TGR). TrxRs catalyze the NADPH-dependent reduction of the redox protein thioredoxin (Trx). TrxR is important in regulating the intracellular redox environment, cell growth and transformation, as well as the recycling of ascorbate from its oxidized form. Trx/TrxR system is associated with the cancers, metabolic syndrome, insulin resistance, and type 2 diabetes, as well as in hypertension and atherosclerosis[1][2].

TrxR Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-138071
    8α-Tigloyloxyhirsutinolide 13-O-acetate
    Inhibitor
    8α-Tigloyloxyhirsutinolide 13-O-acetate is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo.
  • HY-146350
    TrxR-IN-4
    Inhibitor
    TrxR-IN-4 (Compound 1b) is a potent inhibitor of TrxR. TrxR-IN-4 induces HepG2 cells apoptosis by activating the endoplasmic reticulum stress (ERS). TrxR-IN-4 improves the CCl4-induced liver damage in vivo by down-regulation of TrxR expression and inflammation level.