537-09-7
Chemical Structure
Evernic Acid
- CAS No.: 537-09-7
- Formula:C17H16O7
- Molecular Weight:332.30
IUPAC Name: 2-hydroxy-4-((2-hydroxy-4-methoxy-6-methylbenzoyl)oxy)-6-methylbenzoic acid
InChIKey: GODLCSLPZIBRMG-UHFFFAOYSA-N
SMILES: CC1=CC(OC(C2=C(C=C(C=C2O)OC)C)=O)=CC(O)=C1C(O)=O
Biological Activity: Evernic Acid is an orally active thioredoxin reductase 1 (TrxR1) inhibitor and antiproliferative agent. Evernic Acid inhibits the proliferation and migration of human breast cancer cells. Evernic Acid blocks the NF-κB pathway by inhibiting p65 nuclear translocation and IκBα phosphorylation, thereby suppressing downstream inflammatory mediators. Evernic Acid acts as an antioxidant, anti-inflammatory agent and neuroprotective agent, protects neurons from cell death, mitochondrial dysfunction and oxidative stress damage, reduces astrocyte activation, and ameliorates dopaminergic neuron loss and neuroinflammation. Evernic Acid inhibits enoyl reductases FabI and FabZ of Plasmodium falciparum. Evernic Acid downregulates the expression of lasB and rhlA genes in Pseudomonas aeruginosa, inhibits quorum sensing and biofilm formation, and exerts antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Evernic Acid is applicable to research related to breast cancer, Parkinson's disease, bacterial infections and fungal infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Evernic Acid | 99.71% | Evernic Acid is an orally active thioredoxin reductase 1 (TrxR1) inhibitor and antiproliferative agent. Evernic Acid inhibits the proliferation and migration of human breast cancer cells. Evernic Acid blocks the NF-κB pathway by inhibiting p65 nuclear translocation and IκBα phosphorylation, thereby suppressing downstream inflammatory mediators. Evernic Acid acts as an antioxidant, anti-inflammatory agent and neuroprotective agent, protects neurons from cell death, mitochondrial dysfunction and oxidative stress damage, reduces astrocyte activation, and ameliorates dopaminergic neuron loss and neuroinflammation. Evernic Acid inhibits enoyl reductases FabI and FabZ of Plasmodium falciparum. Evernic Acid downregulates the expression of lasB and rhlA genes in Pseudomonas aeruginosa, inhibits quorum sensing and biofilm formation, and exerts antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Evernic Acid is applicable to research related to breast cancer, Parkinson's disease, bacterial infections and fungal infections. | ||||||||||||||||||||
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Evernic Acid (Standard) | ≥98% | Propazine (Standard) is the analytical standard of Propazine. This product is intended for research and analytical applications. Propazine is a triazine herbicide that effectively manages broad-leaved weeds and annual grasses in sweet sorghum cultivation. | ||||||||||||||||||||
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- [1]. Kalın ŞN, et al. Effect of evernic acid on human breast cancer MCF-7 and MDA-MB-453 cell lines via thioredoxin reductase 1: A molecular approach. J Appl Toxicol. 2023;43(8):1148-1158. [Content Brief]
- [2]. Lee S, et al. Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson's Disease Model. Int J Mol Sci. 2021;22(4):2098. Published 2021 Feb 20. [Content Brief]
- [3]. Shcherbakova A, et al. Antimicrobial and antioxidant activity of Evernia prunastri extracts and their isolates. World J Microbiol Biotechnol. 2021;37(8):129. Published 2021 Jul 7. [Content Brief]
Keywords
