2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. TrxR
  5. TrxR1 Isoform

TrxR1

 

TrxR1 Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-168875
    TrxR1 prodrug-1
    		Inhibitor
    TrxR1 prodrug-1 (compound 5u) is a potent inhibitor of TrxR1. TrxR1 prodrug-1 exhibits significant antitumor efficiency in nude mice and NSCLC organoids.
  • HY-183544
    Platinum(IV) Prodrug-1
    		Inhibitor
    Platinum (IV) Prodrug-1 (Compound 6b) is a Pt (IV) prodrug and selective TrxR1 inhibitor. Platinum (IV) Prodrug-1 induces ferroptosis (Ferroptosis) by depleting glutathione, accumulating intracellular lipid peroxides, and inactivating Glutathione peroxidase 4. Platinum (IV) Prodrug-1 triggers endoplasmic reticulum stress and immunogenic cell death via excessive accumulation of intracellular ROS. Platinum (IV) Prodrug-1 exhibits anticancer activity against both Cisplatin (HY-17394)-sensitive and Cisplatin-resistant triple-negative breast cancer cells. Platinum (IV) Prodrug-1 can be used for the research of triple-negative breast cancer.