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Cat. No.: HY-108534

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PMX464

(Synonyms: AW 464)

PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells.

For research use only. We do not sell to patients.

CAS No.: 485842-97-5
Formula: C₁₃H₉NO₂S
Molecular Weight:243.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PMX464 Chemical Structure

CAS No.: 485842-97-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All TrxR Isoforms :

TrxR1
TrxR2

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.5 μM Compound: 1	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 17343370]
A549	IC₅₀	2.35 μM Compound: 7a	Inhibitory activity against A549 lung adenocarcinoma cell line Inhibitory activity against A549 lung adenocarcinoma cell line	[PMID: 12570375]
HCT-116	GI₅₀	0.11 μM Compound: PMX 464	Antitumor activity against human HCT116 cells by MTT assay Antitumor activity against human HCT116 cells by MTT assay	[PMID: 16908135]
HCT-116	IC₅₀	0.03 μM Compound: 1	Growth inhibition of human HCT116 cells after 72 hrs by MTT assay Growth inhibition of human HCT116 cells after 72 hrs by MTT assay	[PMID: 17343370]
HCT-116	IC₅₀	0.04 μM Compound: 7a	Inhibitory activity against HCT116 colon cancer cell line Inhibitory activity against HCT116 colon cancer cell line	[PMID: 12570375]
HT-29	GI₅₀	0.59 μM Compound: PMX 464	Antitumor activity against human HT29 cells by MTT assay Antitumor activity against human HT29 cells by MTT assay	[PMID: 16908135]
HT-29	IC₅₀	0.38 μM Compound: 7a	Inhibitory activity against HT-29 colon cancer cell line Inhibitory activity against HT-29 colon cancer cell line	[PMID: 12570375]
MCF7	GI₅₀	0.44 μM Compound: PMX 464	Antitumor activity against human MCF7 cells by MTT assay Antitumor activity against human MCF7 cells by MTT assay	[PMID: 16908135]
MCF7	IC₅₀	0.35 μM Compound: 7a	Inhibitory activity against MCF-7 mammary carcinoma cell line Inhibitory activity against MCF-7 mammary carcinoma cell line	[PMID: 12570375]
MDA-MB-468	GI₅₀	0.41 μM Compound: PMX 464	Antitumor activity against human MDA-MB-468 cells by MTT assay Antitumor activity against human MDA-MB-468 cells by MTT assay	[PMID: 16908135]
MDA-MB-468	IC₅₀	0.79 μM Compound: 7a	Inhibitory activity against MDA-468 mammary carcinoma cell line Inhibitory activity against MDA-468 mammary carcinoma cell line	[PMID: 12570375]
MRC5	EC₅₀	0.18 μM Compound: 4, PMX 464	Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay	[PMID: 22264753]
Panel NCI-60 (60 carcinoma cell lines)	GI₅₀	0.23 μM Compound: 2	Mean in vitro GI50 value against 60 human cancer cell line was determined Mean in vitro GI50 value against 60 human cancer cell line was determined	[PMID: 15658878]
Panel NCI-60 (60 carcinoma cell lines)	GI₅₀	0.23 μM Compound: PMX 464	Antitumor activity against human NCI60 cells Antitumor activity against human NCI60 cells	[PMID: 16908135]

Chemical Information

CAS No. 485842-97-5
Molecular Weight 243.28
Formula C₁₃H₉NO₂S
SMILES

O=C1C=CC(O)(C2=NC3=CC=CC=C3S2)C=C1
Synonyms

AW 464
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Callister ME, et, al. PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells. Br J Pharmacol. 2008 Nov;155(5):661-72. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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PMX464

High-Throughput Bioactive Compound Library

All TrxR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PMX464 Related Classifications

HY-108534 Related Classifications