Ristocetin A sulfate
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Ristocetin A sulfate (Ristomycin III) is a glycopeptide antibiotic that binds to von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A sulfate interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation, Ristocetin A sulfate drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A sulfate not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A sulfate is widely used in studies related to thromboembolic diseases and bacterial infections.
For research use only. We do not sell to patients.
- Purity: 95.02%
- CAS No.: 90831-71-3
- Formula: C94H110N8O48S
- Molecular Weight:2150.96
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Ristocetin A sulfate (1 mg/mL; 10 min, 45 min) induces the formation of intact, smooth lamellipodia and enhances the adhesion of washed human platelets to immobilized VWF; this effect relies on an αᵢᵢbβ3-dependent, GPIb-independent pathway, and requires PI3-kinase, Src-kinase and intracellular Ca2+ signaling, with an average platelet spreading surface area of 41.0 μm2[1].
Ristocetin A sulfate (1 mg/mL; 900 s) induces rapid, smooth lamellipodial protrusion of human washed platelets on immobilized VWF surfaces; this signaling pathway is dependent on αIIbβ3 and independent of GPIb[1].
Ristocetin A sulfate (1 mg/mL; 45 min) induces the formation of F-actin stress fibers in human washed platelets spread on immobilized VWF, and causes uniform localization of the Arp2/3 complex and talin [1].
Ristocetin A sulfate (1 mg/mL; 4 min) significantly enhances the adhesion and spreading of washed human platelets on immobilized VWF under flow conditions, with an average platelet spreading surface area of 40.4 μm2, and this process depends on the αiibβ3 pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 90831-71-3
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Appearance Solid
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Molecular Weight 2150.96
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Formula C94H110N8O48S
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Color White to off-white
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SMILES
O=C(N[C@H](C(OC)=O)C1=C(C2=C(O)C=CC([C@@H](NC([C@H]3C4=CC(OC5=CC=C([C@@H](O)[C@@H]6C(N[C@H](C(N3)=O)C7=CC(O)=C(C)C(OC8=C(O)C=CC([C@@H](N)C(N6)=O)=C8)=C7)=O)C=C5)=C(O[C@H]9[C@H](O[C@@H]%10[C@@H](O[C@H]%11[C@@H](O)[C@H](O)[C@H](O)CO%11)[C@@H](O)[C@H](O)[C@@H](CO)O%10)[C@@H](O)[C@H](O)[C@@H](CO[C@H]%12[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O%12)O9)C(OC%13=CC=C%14C=C%13)=C4)=O)C(N%15)=O)=C2)C(O[C@H]%16[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O%16)=CC(O)=C1)[C@@H]%15[C@@H]%14O[C@H]%17C[C@@H](N)[C@@H](O)[CH]O%17.OS(O)(=O)=O
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Synonyms
Ristomycin III
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (286 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ristocetin A sulfate Related Classifications
HY-138053 Related Classifications
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