90831-71-3
Chemical Structure
Ristocetin A sulfate
Synonym(s): Ristomycin III
- CAS No.: 90831-71-3
- Formula:C94H110N8O48S
- Molecular Weight:2150.96
InChIKey: VTVVNFZLLJXCCI-HYOHATDSSA-N
SMILES: O=C(N[C@H](C(OC)=O)C1=C(C2=C(O)C=CC([C@@H](NC([C@H]3C4=CC(OC5=CC=C([C@@H](O)[C@@H]6C(N[C@H](C(N3)=O)C7=CC(O)=C(C)C(OC8=C(O)C=CC([C@@H](N)C(N6)=O)=C8)=C7)=O)C=C5)=C(O[C@H]9[C@H](O[C@@H]%10[C@@H](O[C@H]%11[C@@H](O)[C@H](O)[C@H](O)CO%11)[C@@H](O)[C@H](O)[C@@H](CO)O%10)[C@@H](O)[C@H](O)[C@@H](CO[C@H]%12[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O%12)O9)C(OC%13=CC=C%14C=C%13)=C4)=O)C(N%15)=O)=C2)C(O[C@H]%16[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O%16)=CC(O)=C1)[C@@H]%15[C@@H]%14O[C@H]%17C[C@@H](N)[C@@H](O)[CH]O%17.OS(O)(=O)=O
Biological Activity: Ristocetin A sulfate (Ristomycin III) is a glycopeptide antibiotic that binds to von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A sulfate interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation, Ristocetin A sulfate drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A sulfate not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A sulfate is widely used in studies related to thromboembolic diseases and bacterial infections[1][2].
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Ristocetin A sulfate | 95.02% | Ristocetin A sulfate (Ristomycin III) is a glycopeptide antibiotic that binds to von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A sulfate interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation, Ristocetin A sulfate drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A sulfate not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A sulfate is widely used in studies related to thromboembolic diseases and bacterial infections. | ||||||||||||||||||||
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- [1]. Mccarty O J T, et al. von Willebrand factor mediates platelet spreading through glycoprotein Ib and αIIbβ3 in the presence of botrocetin and ristocetin, respectively[J]. Journal of thrombosis and haemostasis, 2006, 4(6): 1367-1378.
- [2]. Nahoum V, et al. Structure of ristocetin A in complex with a bacterial cell-wall mimetic[J]. Biological Crystallography, 2009, 65(8): 832-838.
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