Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols')

  • Bioorg Med Chem Lett. 2006 Oct 1;16(19):5005-8. doi: 10.1016/j.bmcl.2006.07.072.
Cedric J Lion  1 ,  Charles S Matthews ,  Geoffrey Wells ,  Tracey D Bradshaw ,  Malcolm F G Stevens ,  Andrew D Westwell
Affiliations
  • 1. Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
PMID: 16908135 DOI: 10.1016/j.bmcl.2006.07.072
Abstract

The synthesis and in vitro antitumour evaluation of a new series of fluorinated benzothiazole-substituted 4-hydroxycyclohexa-2,5-dienones ('quinols') is described. The new compounds were found to be of comparable activity compared to the non-fluorinated precursor PMX 464, in terms of antiproliferative activity in sensitive human Cancer cell lines (nanomolar GI(50) values) and inhibitory activity against the thioredoxin signalling system.