804-36-4
Chemical Structure
Nitrovin
Synonym(s): Difurazon
- CAS No.: 804-36-4
- Formula:C14H12N6O6
- Molecular Weight:360.28
IUPAC Name: (2,6-dichlorobenzyl)phosphonic acid
InChIKey: XQCFHQBGMWUEMY-ZPUQHVIOSA-N
SMILES: O=[N+](C1=CC=C(/C=C/C(/C=C/C2=CC=C([N+]([O-])=O)O2)=N\NC(N)=N)O1)[O-]
Biological Activity: Nitrovin (Difurazon) is a thioredoxin reductase 1 (TrxR1) inhibitor with both antibacterial and anticancer activities. Nitrovin interacts with TrxR1 to generate reactive oxygen species (ROS), which in turn induces cytoplasmic vacuolization, activates MAPK and inhibits Alix. Nitrovin induces paraptosis-like non-apoptotic cell death, thereby exerting significant cytotoxicity against cancer cells. Nitrovin can be used in the research of heart disease and glioblastoma multiforme[1][2].
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Nitrovin | Nitrovin (Difurazon) is a thioredoxin reductase 1 (TrxR1) inhibitor with both antibacterial and anticancer activities. Nitrovin interacts with TrxR1 to generate reactive oxygen species (ROS), which in turn induces cytoplasmic vacuolization, activates MAPK and inhibits Alix. Nitrovin induces paraptosis-like non-apoptotic cell death, thereby exerting significant cytotoxicity against cancer cells. Nitrovin can be used in the research of heart disease and glioblastoma multiforme. | |||||||||||||||||||||
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- [1]. Zhao L, et al. Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1). Biochemical pharmacology. 2023 Apr;210:115487. [Content Brief]
- [2]. Norio Nakatsuji, et al. Composition for promoting differentiation of pluripotent stem cells into cardiac muscle cells which comprises nitrovin. US20120244619A1. 2010-12-09.
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