2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. TrxR
  5. TrxR Inhibitor

TrxR Inhibitor

TrxR Isoform Comparison

TrxR Inhibitors (16):

Cat. No. Product Name Effect Purity
  • HY-149265
    ROS-generating agent 1
    		Inhibitor 99.57%
    ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities.
  • HY-168875
    TrxR1 prodrug-1
    		Inhibitor
    TrxR1 prodrug-1 (compound 5u) is a potent inhibitor of TrxR1. TrxR1 prodrug-1 exhibits significant antitumor efficiency in nude mice and NSCLC organoids.
  • HY-172115
    BGC4
    		Inhibitor
    BGC4 is a biphenyl-based gold(III) complex. BGC4 inhibits human recombinant thioredoxin reductase (TrxR) with an IC50 of 10.7 μM, exhibits cytotoxicity (IC50 for MDA-MB-231 is 5.4 μM), and induces apoptosis. BGC4 exhibits antitumor efficacy in mouse models.
  • HY-172086
    TrxR-IN-7
    		Inhibitor
    TrxR-IN-7 (14f) is a potent thioredoxin reductase (TrxR) inhibitor with an IC50 value of 3.5 μM. TrxR-IN-7 shows antiproliferative activity. TrxR-IN-7 induces apoptosis and ROS generation.
  • HY-138071
    8α-Tigloyloxyhirsutinolide 13-O-acetate
    		Inhibitor
    8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo.
  • HY-129751
    Nitrovin hydrochloride
    		Inhibitor
    Nitrovin hydrochloride is an antibacterial growth promoter. Nitrovin hydrochloride induces ROS-mediated non-apoptotic and apoptotic-like cell death by targeting TrxR1. Nitrovin hydrochloride has anticancer activity, with IC50 values of 1.31-6.60 μM for tumor and normal cells.
  • HY-149390
    TrxR1-IN-1
    		Inhibitor
    TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC50: 8.8 μM). TrxR1-IN-1 has anticancer activity, with IC50s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM). TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical.
  • HY-157158
    TrxR-IN-6
    		Inhibitor
    TrxR-IN-6 (compound 1d) is a TrxR inhibitor that induces reactive oxygen species (ROS) accumulation and has anticancer activity. TrxR-IN-6 can further lead to redox system collapse, inducing mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and DNA damage. Finally, it causes oxidative stress and induces apoptosis.
  • HY-146350
    TrxR-IN-4
    		Inhibitor
    TrxR-IN-4 (Compound 1b) is a potent inhibitor of TrxR. TrxR-IN-4 induces HepG2 cells apoptosis by activating the endoplasmic reticulum stress (ERS). TrxR-IN-4 improves the CCl4-induced liver damage in vivo by down-regulation of TrxR expression and inflammation level.
  • HY-168874
    TrxR1-IN-2
    		Inhibitor
    TrxR1-IN-2 (Compound 6a) is a TrxR1 inhibitor that covalently binds to the Cys475 and Sec498 sites of TrxR1, thereby inhibiting TrxR1 activity and leading to redox homeostasis disruption, which triggers apoptosis and ferroptosis.
  • HY-163724
    LW-216
    		Inhibitor
    LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity.
  • HY-168492
    TrxR/EGFR-IN-1
    		Inhibitor
    TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib (HY-50895)-sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis. TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis. In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib (HY-50895)-resistant lung cancer.
  • HY-162958
    Photosensitizer-6
    		Inhibitor
    Photosensitizer-6 (Compound 4) is a gold (I) complex and exhibits inhibitory activity against TrxR. Photosensitizer-6 induces apoptosis in 4T1 cell, targets and eradicates tumors through chemo-phototherapy and immunogenic cell death under light exposure. Photosensitizer-6 can be used for tumor imaging.
  • HY-W504391
    Nitrovin
    		Inhibitor
    Nitrovin is an antibacterial growth promoter. Nitrovin induces ROS-mediated non-apoptotic and apoptotic-like cell death by targeting TrxR1. Nitrovin has anticancer activity, with IC50 values of 1.31-6.60 μM for tumor and normal cells.
  • HY-159883
    DDHF20
    		Inhibitor
    DDHF20 is an antimicrobial agent against Staphylococcus aureus, targeting and inhibiting its thioredoxin reductase (TrxR). It acts as a competitive inhibitor for the NADPH binding site. DDHF20 is expected to be used in research related to antimicrobial infections caused by Staphylococcus aureus.
  • HY-120914
    TrxR1-IN-B19
    		Inhibitor
    TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis.