1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. TrxR
  4. TrxR Inhibitor

TrxR Inhibitor

TrxR Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-138071
    8α-Tigloyloxyhirsutinolide 13-O-acetate
    Inhibitor
    8α-Tigloyloxyhirsutinolide 13-O-acetate is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo.
  • HY-146350
    TrxR-IN-4
    Inhibitor
    TrxR-IN-4 (Compound 1b) is a potent inhibitor of TrxR. TrxR-IN-4 induces HepG2 cells apoptosis by activating the endoplasmic reticulum stress (ERS). TrxR-IN-4 improves the CCl4-induced liver damage in vivo by down-regulation of TrxR expression and inflammation level.