TrxR1-IN-1
TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC50: 8.8 μM). TrxR1-IN-1 has anticancer activity, with IC50s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM). TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical.
For research use only. We do not sell to patients.
- CAS No.: 3052303-04-2
- Formula: C23H18N2O4Se
- Molecular Weight:465.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
8.8 μM (TrxR1)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.1 μM
Compound: 5j
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Cytotoxicity against human A549 cells measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human A549 cells measured after 24 to 72 hrs by MTT assay
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[PMID: 37482018] |
| BGC-823 | IC50 |
2.4 μM
Compound: 5j
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Cytotoxicity against human BGC-823 cells measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human BGC-823 cells measured after 24 to 72 hrs by MTT assay
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[PMID: 37482018] |
| HeLa | IC50 |
1.7 μM
Compound: 5j
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Cytotoxicity against human HeLa cells measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human HeLa cells measured after 24 to 72 hrs by MTT assay
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[PMID: 37482018] |
| MCF7 | IC50 |
1.5 μM
Compound: 5j
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Cytotoxicity against human MCF7 cells measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells measured after 24 to 72 hrs by MTT assay
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[PMID: 37482018] |
| SW480 | IC50 |
2.8 μM
Compound: 5j
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Cytotoxicity against human SW480 cells measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human SW480 cells measured after 24 to 72 hrs by MTT assay
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[PMID: 37482018] |
Chemical Information
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CAS No. 3052303-04-2
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Molecular Weight 465.36
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Formula C23H18N2O4Se
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SMILES
O=C1N(C2=CC=C(CNC(C3=C(C=CC=C3)OC(C)=O)=O)C=C2)[Se]C4=CC=CC=C41
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TrxR1-IN-1 Related Classifications
HY-149390 Related Classifications
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