TrxR1-IN-1
TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC50: 8.8 μM). TrxR1-IN-1 has anticancer activity, with IC50s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM). TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical.
For research use only. We do not sell to patients.
- CAS No.: 3052303-04-2
- Formula: C23H18N2O4Se
- Molecular Weight:465.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
8.8 μM (TrxR1)[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.1 μM
Compound: 5j
|
Cytotoxicity against human A549 cells measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human A549 cells measured after 24 to 72 hrs by MTT assay
|
[PMID: 37482018] |
| BGC-823 | IC50 |
2.4 μM
Compound: 5j
|
Cytotoxicity against human BGC-823 cells measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human BGC-823 cells measured after 24 to 72 hrs by MTT assay
|
[PMID: 37482018] |
| HeLa | IC50 |
1.7 μM
Compound: 5j
|
Cytotoxicity against human HeLa cells measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human HeLa cells measured after 24 to 72 hrs by MTT assay
|
[PMID: 37482018] |
| MCF7 | IC50 |
1.5 μM
Compound: 5j
|
Cytotoxicity against human MCF7 cells measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells measured after 24 to 72 hrs by MTT assay
|
[PMID: 37482018] |
| SW480 | IC50 |
2.8 μM
Compound: 5j
|
Cytotoxicity against human SW480 cells measured after 24 to 72 hrs by MTT assay
Cytotoxicity against human SW480 cells measured after 24 to 72 hrs by MTT assay
|
[PMID: 37482018] |
Chemical Information
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CAS No. 3052303-04-2
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Molecular Weight 465.36
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Formula C23H18N2O4Se
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SMILES
O=C1N(C2=CC=C(CNC(C3=C(C=CC=C3)OC(C)=O)=O)C=C2)[Se]C4=CC=CC=C41
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)