1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

Teprenone (Synonyms: Geranylgeranylacetone)

Cat. No.: HY-B0779 Purity: >98.0%
Handling Instructions

Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).

For research use only. We do not sell to patients.

Teprenone Chemical Structure

Teprenone Chemical Structure

CAS No. : 6809-52-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
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Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
500 mg USD 180 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
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    Teprenone purchased from MCE. Usage Cited in: Phytother Res. 2018 Jul;32(7):1320-1331.

    Panc-28 cells are treated with GGA (20 μM) for 48 hr and the expression of HSPA8 is determined using western blot.

    Teprenone purchased from MCE. Usage Cited in: Phytother Res. 2018 Jul;32(7):1320-1331.

    Panc-28 cells are treated with VER-155008 (20 μM) for 48 hr, and the expression of HSPA8 is determined using western blot

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    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).

    IC50 & Target[1]

    HSP

     

    In Vitro

    Teprenone is an inducer of HSPs. Teprenone (Geranylgeranylacetone, 1 μM) significantly prevents ethanol-induced exfoliation, and reduces lactate dehydrogenase (LDH) release in gastric mucosal cells. Teprenone (1 μM) gradually increases HSC70 level, and rapidly accumulates the stress-inducible HSP90, HSP70, and HSP60 concentrations within 30-60 min. Teprenone also activates the heat shock factor 1[1]. Teprenone (0-20 µM) slightly increases human umbilical vein endothelial cell (HUVEC) viability following irradiation (IR). Teprenone (10 µM) exhibits no effects on HUVEC migration and invasion, but enhances HUVEC tube formation and wound healing both with and without IR. Teprenone (10 µM) also promotes angiogenesis by inducing VEGF and eNOS expression in HUVECs[3].

    In Vivo

    Teprenone (200 mg/kg, p.o.) results in the accumulation of HSP70 mRNA in rats, and the accumulation is enhanced by stress addition in the mucosa of Teprenone-pretreated rats compared with that of vehicle-pretreated rats. Teprenone (200 mg/kg, p.o.) markedly suppresses the ulcer formation after 2- and 4-hour stress loading in rats[1]. Teprenone (200 mg/kg daily) induces HSP72 in retinal ganglion cells (RGCs) from rat retinas. Teprenone significantly reduces the loss of RGCs (evaluated after intraocular pressure (IOP) elevation), lessens optic nerve damage, decreases the number of TUNEL-positive cells in the RGC layer, and increases HSP72 in a rat model of glaucoma[2]. Teprenone (200 mg/kg, p.o.) shows protective effect on radiation-induced intestinal injury in mice[3].

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 32 mg/mL (96.81 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0253 mL 15.1263 mL 30.2526 mL
    5 mM 0.6051 mL 3.0253 mL 6.0505 mL
    10 mM 0.3025 mL 1.5126 mL 3.0253 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Cell Assay
    [3]

    Human umbilical vein endothelial cells (HUVECs) are seeded onto 48-well plates at a density of 1 × 102 cells/well before Teprenone and/or radiation treatment. Cell viability is determined at 48 h after treatment using 0.5 mg/mL MTT solution in serum-free media. This solution is incubated with the cells for 2 h in the 37°C humidified atmosphere containing 5% CO2. Then, the MTT solution is removed, and the cells are dissolved in 100 µL of DMSO. Optical densities of the supernatants are measured at 540 nm with an ELISA spectrophotometer[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [1]

    Male Wister strain rats weighing approximately 250 g are individually housed in wire-mesh cages in a room maintained at 23°C on a 12-hour light-dark cycle. Rats are allowed free access to a standard laboratory chow. Teprenone (200 mg/kg; as emulsion with 5% gum arabic and 0.008% α-tocopherol) or vehicle (5% gum arabic emulsion containing 0.008% α-tocopherol) is given orally in a volume of 5 mL/kg through a metal tubing attached to a 6-mL syringe. Two hours later, rats are placed in restraint cages and then vertically immersed in water at 23°C to the level of the xyphoid process. The rats are killed by decapitation at the indicated times[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    Molecular Weight

    330.55

    Formula

    C₂₃H₃₈O

    CAS No.

    6809-52-5

    SMILES

    CC(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=O

    Storage
    Pure form -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: >98.0%

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    Product Name:
    Teprenone
    Cat. No.:
    HY-B0779
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    Teprenone

    Cat. No.: HY-B0779