1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

Teprenone (Synonyms: Geranylgeranylacetone)

Cat. No.: HY-B0779 Purity: >98.0%
Handling Instructions

Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).

For research use only. We do not sell to patients.

Teprenone Chemical Structure

Teprenone Chemical Structure

CAS No. : 6809-52-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
500 mg USD 180 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
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5 g   Get quote  

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View All HSP Isoform Specific Products:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).

IC50 & Target[1]

HSP

 

In Vitro

Teprenone is an inducer of HSPs. Teprenone (Geranylgeranylacetone, 1 μM) significantly prevents ethanol-induced exfoliation, and reduces lactate dehydrogenase (LDH) release in gastric mucosal cells. Teprenone (1 μM) gradually increases HSC70 level, and rapidly accumulates the stress-inducible HSP90, HSP70, and HSP60 concentrations within 30-60 min. Teprenone also activates the heat shock factor 1[1]. Teprenone (0-20 µM) slightly increases human umbilical vein endothelial cell (HUVEC) viability following irradiation (IR). Teprenone (10 µM) exhibits no effects on HUVEC migration and invasion, but enhances HUVEC tube formation and wound healing both with and without IR. Teprenone (10 µM) also promotes angiogenesis by inducing VEGF and eNOS expression in HUVECs[3].

In Vivo

Teprenone (200 mg/kg, p.o.) results in the accumulation of HSP70 mRNA in rats, and the accumulation is enhanced by stress addition in the mucosa of Teprenone-pretreated rats compared with that of vehicle-pretreated rats. Teprenone (200 mg/kg, p.o.) markedly suppresses the ulcer formation after 2- and 4-hour stress loading in rats[1]. Teprenone (200 mg/kg daily) induces HSP72 in retinal ganglion cells (RGCs) from rat retinas. Teprenone significantly reduces the loss of RGCs (evaluated after intraocular pressure (IOP) elevation), lessens optic nerve damage, decreases the number of TUNEL-positive cells in the RGC layer, and increases HSP72 in a rat model of glaucoma[2]. Teprenone (200 mg/kg, p.o.) shows protective effect on radiation-induced intestinal injury in mice[3].

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.0253 mL 15.1263 mL 30.2526 mL
5 mM 0.6051 mL 3.0253 mL 6.0505 mL
10 mM 0.3025 mL 1.5126 mL 3.0253 mL
Please refer to the solubility information to select the appropriate solvent.
Cell Assay
[3]

Teprenone is dissolved in DMSO.

Human umbilical vein endothelial cells (HUVECs) are seeded onto 48-well plates at a density of 1 × 102 cells/well before Teprenone and/or radiation treatment. Cell viability is determined at 48 h after treatment using 0.5 mg/mL MTT solution in serum-free media. This solution is incubated with the cells for 2 h in the 37°C humidified atmosphere containing 5% CO2. Then, the MTT solution is removed, and the cells are dissolved in 100 µL of DMSO. Optical densities of the supernatants are measured at 540 nm with an ELISA spectrophotometer[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Teprenone in formulated in 5% gum arabic emulsion containing 0.008% α-tocopherol.

Male Wister strain rats weighing approximately 250 g are individually housed in wire-mesh cages in a room maintained at 23°C on a 12-hour light-dark cycle. Rats are allowed free access to a standard laboratory chow. Teprenone (200 mg/kg; as emulsion with 5% gum arabic and 0.008% α-tocopherol) or vehicle (5% gum arabic emulsion containing 0.008% α-tocopherol) is given orally in a volume of 5 mL/kg through a metal tubing attached to a 6-mL syringe. Two hours later, rats are placed in restraint cages and then vertically immersed in water at 23°C to the level of the xyphoid process. The rats are killed by decapitation at the indicated times[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

330.55

Formula

C₂₃H₃₈O

CAS No.

6809-52-5

SMILES

CC(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=O

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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Product Name:
Teprenone
Cat. No.:
HY-B0779
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