2866261-50-7
Chemical Structure
TrxR-IN-2
- CAS. Nr.: 2866261-50-7
- Formula:C22H22N4O4
- Molecular Weight:406.43
IUPAC Name: 1,1'-((2E,2'E)-3,3'-(3,6-dimethylpyrazine-2,5-diyl)bis(acryloyl))bis(5,6-dihydropyridin-2(1H)-one)
InChIKey: CRAYTIJKMJDEDI-WGDLNXRISA-N
SMILES: O=C1C=CCCN1C(/C=C/C2=NC(C)=C(/C=C/C(N3CCC=CC3=O)=O)N=C2C)=O
Biological Activity: TrxR-IN-2 is a thioredoxin reductase (TrxR) inhibitor. TrxR-IN-2 increases reactive oxidative species (ROS) levels and decreases mitochondrial transmembrane potential levels. TrxR-IN-2 triggers DNA damage via H2AX regulation, and induces autophagy via LC3, beclin-1, and p62 regulation. TrxR-IN-2 can be used for the research of drug-resistant hepatocellular carcinoma[1].
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TrxR-IN-2 | TrxR-IN-2 is a thioredoxin reductase (TrxR) inhibitor. TrxR-IN-2 increases reactive oxidative species (ROS) levels and decreases mitochondrial transmembrane potential levels. TrxR-IN-2 triggers DNA damage via H2AX regulation, and induces autophagy via LC3, beclin-1, and p62 regulation. TrxR-IN-2 can be used for the research of drug-resistant hepatocellular carcinoma. | |||||||||||||||||||||
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