DVD-445
Based on 1 Customer Validation
DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application.
For research use only. We do not sell to patients.
- Purity: 98.36%
- CAS No.: 2375846-41-4
- Formula: C25H28F2N2O4
- Molecular Weight:458.50
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 0.60 μM (rat TrxR1)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HaCaT | IC50 |
8.3 μM
Compound: 7; DVD-445
|
Cytotoxicity against human HaCaT assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HaCaT assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 31400708] |
| MRC5 | IC50 |
11.85 μM
Compound: DVD-445
|
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 32087464] |
| PBMC | IC50 |
55.71 μM
Compound: 7; DVD-445
|
Cytotoxicity against human PBMC assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human PBMC assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 31400708] |
| SH-SY5Y | IC50 |
10.99 μM
Compound: 7; DVD-445
|
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 31400708] |
| SH-SY5Y | IC50 |
7.26 μM
Compound: 7; DVD-445
|
Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's method
Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's method
|
[PMID: 31400708] |
| U-87MG ATCC | IC50 |
8.9 μM
Compound: DVD-445
|
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 32087464] |
| U-87MG ATCC | IC50 |
9.7 μM
Compound: 7; DVD-445
|
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 31400708] |
DVD-445 (Compound 7) shows a cytotoxic effect in SH-SY5Y, U87, HaCaT cell lines and PBMCs with IC50s of 10.99 μM, 9.70 μM, 8.30 μM, 55.71 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2375846-41-4
-
Appearance Solid
-
Molecular Weight 458.50
-
Formula C25H28F2N2O4
-
Color White to off-white
-
SMILES
O=C(OCCN(C(C1=CC=C(F)C=C1)C(NC(C)(C)C)=O)C)/C=C/C(C2=CC=C(F)C=C2)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (218.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (269 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1810 mL | 10.9051 mL | 21.8103 mL | 54.5256 mL |
| 5 mM | 0.4362 mL | 2.1810 mL | 4.3621 mL | 10.9051 mL | |
| 10 mM | 0.2181 mL | 1.0905 mL | 2.1810 mL | 5.4526 mL | |
| 15 mM | 0.1454 mL | 0.7270 mL | 1.4540 mL | 3.6350 mL | |
| 20 mM | 0.1091 mL | 0.5453 mL | 1.0905 mL | 2.7263 mL | |
| 25 mM | 0.0872 mL | 0.4362 mL | 0.8724 mL | 2.1810 mL | |
| 30 mM | 0.0727 mL | 0.3635 mL | 0.7270 mL | 1.8175 mL | |
| 40 mM | 0.0545 mL | 0.2726 mL | 0.5453 mL | 1.3631 mL | |
| 50 mM | 0.0436 mL | 0.2181 mL | 0.4362 mL | 1.0905 mL | |
| 60 mM | 0.0364 mL | 0.1818 mL | 0.3635 mL | 0.9088 mL | |
| 80 mM | 0.0273 mL | 0.1363 mL | 0.2726 mL | 0.6816 mL | |
| 100 mM | 0.0218 mL | 0.1091 mL | 0.2181 mL | 0.5453 mL |
DVD-445 Related Classifications
HY-126322 Related Classifications
Powered by Bioz