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DVD-445 

Cat. No.: HY-126322
Handling Instructions

DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application.

For research use only. We do not sell to patients.

DVD-445 Chemical Structure

DVD-445 Chemical Structure

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Description

DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application[1].

IC50 & Target

IC50: 0.60 μM (rat TrxR1)[1]

In Vitro

DVD-445 (Compound 7) shows a cytotoxic effect in SH-SY5Y, U87, HaCaT cell lines and PBMCs with IC50s of 10.99 μM, 9.70 μM, 8.30 μM, 55.71 μM, respectively[1].

Molecular Weight

458.50

Formula

C₂₅H₂₈F₂N₂O₄

SMILES

O=C(OCCN(C(C1=CC=C(F)C=C1)C(NC(C)(C)C)=O)C)/C=C/C(C2=CC=C(F)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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DVD-445
Cat. No.:
HY-126322
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