9074-14-0
9074-14-0
Chemical Structure
Thioredoxin reductase
Synonym(s): TrxR
- CAS No.: 9074-14-0
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Thioredoxin reductase]
Biological Activity: Thioredoxin reductase (TrxR) is a selenocysteine-containing NADPH-dependent disulfide oxidoreductase derived from rat liver that utilizes NADPH to reduce oxidized thioredoxin. Thioredoxin reductase can utilize the reducing capacity of human erythrocytes to study the uptake and reduction of α-Lipoic Acid (HY-N0492), and can also be used to investigate the activation mechanism of transglutaminase 2 (TG2) in the extracellular matrix using thioredoxin[1][2][3].
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Thioredoxin reductase | Thioredoxin reductase (TrxR) is a selenocysteine-containing NADPH-dependent disulfide oxidoreductase derived from rat liver that utilizes NADPH to reduce oxidized thioredoxin. Thioredoxin reductase can utilize the reducing capacity of human erythrocytes to study the uptake and reduction of α-Lipoic Acid (HY-N0492), and can also be used to investigate the activation mechanism of transglutaminase 2 (TG2) in the extracellular matrix using thioredoxin. | |||||||||||||||||||||
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References
- [1]. Zhang L, et al. Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms. Free radical biology & medicine. 2016 Oct;99:426-435.
- [2]. May JM, et al. Uptake and reduction of alpha-lipoic acid by human erythrocytes. Clin Biochem. 2007 Oct;40(15):1135-42.
- [3]. Jin X, et al. Activation of extracellular transglutaminase 2 by thioredoxin. J Biol Chem. 2011 Oct 28;286(43):37866-73.
