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Cat. No.: HY-146124

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ATX inhibitor 21

ATX inhibitor 21 (compound 8) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 3490 nM.

For research use only. We do not sell to patients.

CAS No.: 2691936-89-5
Formula: C₂₆H₂₅F₂N₅O₂S
Molecular Weight:509.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ATX inhibitor 21 Chemical Structure

CAS No.: 2691936-89-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ATX inhibitor 21 (compound 8) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 3490 nM^[1].

IC₅₀ & Target

Autotaxin

3490 ± 170 nM (IC₅₀)

All Phosphodiesterase (PDE) Isoforms :

Chemical Information

CAS No. 2691936-89-5
Molecular Weight 509.57
Formula C₂₆H₂₅F₂N₅O₂S
SMILES

FC(C=C1/C=N/NC(C2=CN(CC)C3=CC=C(C4=NC(CN5CCOCC5)=CS4)C=C23)=O)=C(C=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jia F, et al. Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors. Bioorg Med Chem. 2020 Nov 15;28(22):115795. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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ATX inhibitor 21

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ATX inhibitor 21 Related Classifications

HY-146124 Related Classifications