2. Anti-infection
  3. Bacterial
  4. Fmoc-Glu-OMe

Fmoc-Glu-OMe is a glutamic acid derivative. Fmoc-Glu-OMe exhibits significant antibacterial activity and excellent gelation properties in silver nitrate (AgNO3) solution. Fmoc-Glu-OMe promotes wound healing in rat models and eliminates bacteria in MRSA-infected rat wound models. Fmoc-Glu-OMe can be used in studies related to wound infections and MRSA-infected wounds.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Fmoc-Glu-OMe

Fmoc-Glu-OMe Chemical Structure

CAS No. : 145038-49-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 g In-stock
10 g In-stock
25 g In-stock
100 g In-stock
500 g In-stock
> 100 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Fmoc-Glu-OMe Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fmoc-Glu-OMe is a glutamic acid derivative. Fmoc-Glu-OMe exhibits significant antibacterial activity and excellent gelation properties in silver nitrate (AgNO3) solution. Fmoc-Glu-OMe promotes wound healing in rat models and eliminates bacteria in MRSA-infected rat wound models. Fmoc-Glu-OMe can be used in studies related to wound infections and MRSA-infected wounds[1][2].

IC50 & Target

Bacteria[1]
In Vitro

Fmoc-Glu-OMe hydrogel exhibits measurable antibacterial activity against E. coli[1].
Fmoc-Glu-OMe hydrogel (FHAg-15) (FHAg-15 hydrogel at pH 6.0; 16 h) exhibits potent broad-spectrum antibacterial activity against E. coli, S. aureus, P. aeruginosa, and methicillin-resistant S. aureus (MRSA) in vitro, as determined by the disk diffusion assay[2].
Fmoc-Glu-OMe hydrogel (FHAg-15) (FHAg-15 hydrogel; 24 h) potently inhibits biofilm formation of Staphylococcus aureus (to 7.6% of the control level) and Escherichia coli (to 29.8% of the control level) in vitro[2].
Fmoc-Glu-OMe hydrogel (FHAg-15) (pH 4.0-7.4; 24 h; 48 h) significantly promotes NIH-3 T3 cell migration and in vitro wound healing under pH 6.0 and 7.4 conditions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-Glu-OMe Related Antibodies
In Vivo

Fmoc-Glu-OMe hydrogel (FHAg-10/15) (500 μL; topical administration) achieves a wound healing rate of 93.01% within 12 days; in a rat MRSA-infected full-thickness wound model, the FHAg-15 hydrogel prepared from Fmoc-Glu-OMe (500 μL; topical administration) achieves an MRSA clearance rate of 99.9% and a wound healing rate of 97.07% within 12 days[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male, 180-220 g, MRSA-infected full-thickness wound model)[2]
Dosage: 500 μL FHAg-10 hydrogel (formulated with Fmoc-Glu-OMe, HEC, 10 mM AgNO3); 500 μL FHAg-15 hydrogel (formulated with Fmoc-Glu-OMe, HEC, 15 mM AgNO3)
Administration: topical
Result: Achieved a wound healing rate of 54.75% on day 6 and 93.01% on day 12 (FHAg-10 hydrogel).
Achieved a wound healing rate of 67.1% on day 6 and 97.07% on day 12, with visible scabbing (FHAg-15 hydrogel).
Achieved a 99.9% bacterial eradication rate against MRSA by day 6 (FHAg-15 hydrogel).
Showed only scattered inflammatory cells by day 6, and complete healing with skin tissue regeneration and no inflammatory cells by day 12 via histological analysis (FHAg-15 hydrogel).
Molecular Weight

383.40

Formula

C21H21NO6
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (260.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6082 mL 13.0412 mL 26.0824 mL
5 mM 0.5216 mL 2.6082 mL 5.2165 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

SDS (396 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6082 mL 13.0412 mL 26.0824 mL 65.2061 mL
5 mM 0.5216 mL 2.6082 mL 5.2165 mL 13.0412 mL
10 mM 0.2608 mL 1.3041 mL 2.6082 mL 6.5206 mL
15 mM 0.1739 mL 0.8694 mL 1.7388 mL 4.3471 mL
20 mM 0.1304 mL 0.6521 mL 1.3041 mL 3.2603 mL
25 mM 0.1043 mL 0.5216 mL 1.0433 mL 2.6082 mL
30 mM 0.0869 mL 0.4347 mL 0.8694 mL 2.1735 mL
40 mM 0.0652 mL 0.3260 mL 0.6521 mL 1.6302 mL
50 mM 0.0522 mL 0.2608 mL 0.5216 mL 1.3041 mL
60 mM 0.0435 mL 0.2174 mL 0.4347 mL 1.0868 mL
80 mM 0.0326 mL 0.1630 mL 0.3260 mL 0.8151 mL
100 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.6521 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Fmoc-Glu-OMe Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-Glu-OMe145038-49-9Bacterialglutamic acid derivativeE. coliS. aureusP. aeruginosaMRSASprague DawleyratinfectionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Fmoc-Glu-OMe
Cat. No.:
HY-W041988
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (396 KB) Français - FR (396 KB) Deutsch - DE (396 KB) Norwegian - NO (396 KB) Español - ES (396 KB) Swedish - SV (396 KB) Italian - IT (396 KB) Korean - KR (396 KB) Portuguese - PT (396 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.