1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. BMS493

BMS493 

Cat. No.: HY-108529 Purity: 98.46%
Handling Instructions

BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation.

For research use only. We do not sell to patients.

BMS493 Chemical Structure

BMS493 Chemical Structure

CAS No. : 215030-90-3

Size Price Stock Quantity
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 300 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation[1][2].

IC50 & Target[1]

RAR

 

In Vitro

BMS493 (100 nM; 6 days; ALDHhi UCB cells) treatment shows a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls. Newly expanded ALDHhi cells shows increased numbers of CD34 and CD133-positive cells, as well as a reduction in CD38 expression, a marker of hematopoietic cell differentiation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: ALDHhi UCB cells
Concentration: 100 nM
Incubation Time: 6 days
Result: Showed a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls.
In Vivo

Intrapancreatic transplantation of cell progeny after expansion of ALDHhi cells with or without BMS493 shows no reduction of hyperglycemia in Streptozotocin-treated NOD/SCID mice. Thus, Umbilical cord blood (UCB)-derived ALDHhi cells effectively lost islet regenerative capacity during ex vivo expansion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

404.50

Formula

C₂₉H₂₄O₂

CAS No.

215030-90-3

SMILES

O=C(O)C1=CC=C(/C=C/C2=CC=C3C(C)(C)CC=C(C#CC4=CC=CC=C4)C3=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (123.61 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4722 mL 12.3609 mL 24.7219 mL
5 mM 0.4944 mL 2.4722 mL 4.9444 mL
10 mM 0.2472 mL 1.2361 mL 2.4722 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (5.14 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (5.14 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BMS493BMS 493BMS-493RAR/RXRRetinoic acid receptorsRetinoid X receptorsInverseretinoicaciddifferentiationregenerativeisletALDHhicorepressorInhibitorinhibitorinhibit

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Product Name:
BMS493
Cat. No.:
HY-108529
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