215030-90-3
Chemical Structure
BMS493
- No. CAS: 215030-90-3
- Formula:C29H24O2
- Molecular Weight:404.50
IUPAC Name: (E)-4-(2-(5,5-dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl)vinyl)benzoic acid
InChIKey: YCADIXLLWMXYKW-CMDGGOBGSA-N
SMILES: O=C(O)C1=CC=C(/C=C/C2=CC=C3C(C)(C)CC=C(C#CC4=CC=CC=C4)C3=C2)C=C1
Biological Activity: BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation[1][2]. BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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BMS493 | 99.44% | BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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BMS493 (Standard) | ≥98% | BMS493 (Standard) is the analytical standard of BMS493 (HY-108529). This product is intended for research and analytical applications. BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Similarity Score 0.74
HY-100608BMS453 -
Similarity Score 0.66
HY-105689AGN 192870 -
Similarity Score 0.63
HY-119518BMS641 -
Similarity Score 0.61
HY-U00449GAGN 193109 (GMP) -
Similarity Score 0.59
HY-118420BMS-185411 -
Similarity Score 0.56
HY-U00449AAGN 193109 sodium -
Similarity Score 0.56
HY-16683AGN 205728 -
Similarity Score 0.56
HY-186156RARγ antagonist 1 -
Similarity Score 0.53
HY-U00449SAGN 193109-d7 -
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References
- [1]. Elgamal RM, et al. BMS 493 Modulates Retinoic Acid-Induced Differentiation During Expansion of Human Hematopoietic Progenitor Cells for Islet Regeneration. Stem Cells Dev. 2018 Aug 1;27(15):1062-1075. [Content Brief]
- [2]. Yu Z, et al. Apoptosis induced by atRA in MEPM cells is mediated through activation of caspase and RAR. Toxicol Sci. 2006 Feb;89(2):504-9. [Content Brief]
