Cat. No.: HY-B0946

Sulfamonomethoxine

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 1220-83-3
Formula: C₁₁H₁₂N₄O₃S
Molecular Weight:280.30

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Sulfamonomethoxine Chemical Structure

CAS No.: 1220-83-3

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Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
T-cell	IC₅₀	>400 nM Compound: 22	Cytoprotective activity against mouse PD-1 stimulated T cell assessed as rescue of PD-1 stimulated inhibition of IFN-gamma production by ELISA Cytoprotective activity against mouse PD-1 stimulated T cell assessed as rescue of PD-1 stimulated inhibition of IFN-gamma production by ELISA	[PMID: 33454550]

In Vitro

Sulfamonomethoxine (72 h) can inhibit the growth of Chlorella vulgaris and Isochrysis galbana, with the EC₅₀ values of 5.9 and 9.7 mg/L, respectively^[1].
Sulfamonomethoxine (48 h) is toxic to Daphnia magna and Daphnia similis, which can lead to their death, with LC₅₀ values of 48 and 283 mg/L, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic Analysis in Fish (Anguilla japonica)^[2]

Route and Dose (mg/kg)	Ke (h^-1)	K₁₂ (h^-1)	K₂₁ (h^-1)	T_1/2α (h)	T_1/2β (h)	AUC (μg·h/mL)	MRT (h)	Cl_B (mL/kg/h)	V_ss (L/kg)	V_C (L/kg)
i.v. and 200	0.025	1.91	0.82	0.25	86.6	59100	129	3.38	0.45	0.14

Route and Dose (mg/kg)	Ka (h^-1)	Ke (h^-1)	Ta_1/2 (h)	T_1/2 (h)	AUC (μg·h/mL)	MRT (h)
p.o. and 400	0.064	0.005	10.8	139	28400	232

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1220-83-3
Appearance Solid
Molecular Weight 280.30
Formula C₁₁H₁₂N₄O₃S
Color White to off-white
SMILES

O=S(C1=CC=C(N)C=C1)(NC2=NC=NC(OC)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Antibiotics (Basel)

Revitalizing Trimethoprim/Sulfamethoxazole via Nanotechnology for Improved Pharmacokinetics and Antibacterial Efficacy. [Abstract]

2026 Mar 10;15(3):283. PMID: 41892445

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (356.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5676 mL

17.8380 mL

35.6761 mL

5 mM

0.7135 mL

3.5676 mL

7.1352 mL

10 mM

0.3568 mL

1.7838 mL

3.5676 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang DJ, et al. Toxicity of the veterinary sulfonamide antibiotic sulfamonomethoxine to five aquatic organisms. Environ Toxicol Pharmacol. 2014 Nov;38(3):874-80. [Content Brief]

[2]. Ryuji Ueno. Pharmacokinetics and Bioavailability of Sulfamonomethoxine in Cultured Eel. Fish Pathology,33(4),297-301,1998.10.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.5676 mL	17.8380 mL	35.6761 mL	89.1902 mL
	5 mM	0.7135 mL	3.5676 mL	7.1352 mL	17.8380 mL
	10 mM	0.3568 mL	1.7838 mL	3.5676 mL	8.9190 mL
	15 mM	0.2378 mL	1.1892 mL	2.3784 mL	5.9460 mL
	20 mM	0.1784 mL	0.8919 mL	1.7838 mL	4.4595 mL
	25 mM	0.1427 mL	0.7135 mL	1.4270 mL	3.5676 mL
	30 mM	0.1189 mL	0.5946 mL	1.1892 mL	2.9730 mL
	40 mM	0.0892 mL	0.4460 mL	0.8919 mL	2.2298 mL
	50 mM	0.0714 mL	0.3568 mL	0.7135 mL	1.7838 mL
	60 mM	0.0595 mL	0.2973 mL	0.5946 mL	1.4865 mL
	80 mM	0.0446 mL	0.2230 mL	0.4460 mL	1.1149 mL
	100 mM	0.0357 mL	0.1784 mL	0.3568 mL	0.8919 mL

Keywords

Sulfamonomethoxine

1 Cited Publications

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Sulfamonomethoxine

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Publications Citing Use of MedChemExpress (MCE) Sulfamonomethoxine

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Sulfamonomethoxine

Anti-Infection Compound Library

FDA-Approved Drug Library

Peptidomimetic Library

Drug Repurposing Compound Library

Antibacterial Compound Library

Anti-COVID-19 Compound Library

NMPA-Approved Drug Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Antibiotics Library

Human Metabolite Library

Off-patent Drug Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Sulfamonomethoxine

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Sulfamonomethoxine Related Classifications

HY-B0946 Related Classifications