Sulfamonomethoxine sodium

Name: Sulfamonomethoxine sodium
Brand: MedChemExpress
SKU: HY-W097570
Rating: 4.5 (1 reviews)

Cat. No.: HY-W097570 Purity: 99.88%: Data Sheet
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Sulfamonomethoxine sodium is an orally active broad-spectrum synthetic sulfonamide antibiotic that inhibits dihydropteroate synthetase. Sulfamonomethoxine sodium increases blood glucose levels, induces anxiety-related activities and impairs spatial learning and memory. Sulfamonomethoxine sodium can be used for the research of anxiety, spatial memory impairment, colisepticemia, salmonellosis, and staphylococcus infection.

For research use only. We do not sell to patients.

Sulfamonomethoxine sodium Chemical Structure

CAS No. : 38006-08-5

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote
5 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Sulfamonomethoxine sodium:

Sulfamonomethoxine In-stock
Sulfamonomethoxine sodium (Standard) Get quote

1 Publications Citing Use of MCE Sulfamonomethoxine sodium

•Antibiotics (Basel). 2026 Mar 10;15(3):283.

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: antibacterial^[1]

In Vivo

Sulfamonomethoxine sodium (10-200 mg/kg/day; p.o.; daily for 18 days) during gestation causes dose-dependent, sex-specific physiological changes^[1].
Sulfamonomethoxine sodium (43.6-65.5 mg/kg; p.o.; daily for 7 days) results in prolonged residue retention in laying hen eggs, with maximal concentrations reached 2 days post-treatment^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ICR (female)^[1]
Dosage:	10 mg/kg/day; 50 mg/kg/day; 200 mg/kg/day
Administration:	p.o.; daily; GD 1-18
Result:	Increased blood glucose levels in both male (p < 0.05) and female (p < 0.01) offspring at PND 22 with 200 mg/kg/day exposure. Reduced kidney coefficients in male offspring (p < 0.05) at PND 22 with 200 mg/kg/day exposure. Reduced serum BH₄ levels to 5.7 pg/mL (p < 0.05) and BDNF levels to 162.5 pg/mL (p < 0.01) in male offspring at PND 22 with 200 mg/kg/day exposure. Reduced body weight in male offspring at PND 35 (p < 0.05) with 10 mg/kg/day exposure compared to controls. Reduced body weight in female offspring at PND 28 (p < 0.01) with 10 mg/kg/day exposure compared to controls. Reduced total distance traveled (p < 0.05) and number of squares crossed (p < 0.05) in both male and female offspring at PND 50 with 50 mg/kg/day exposure. Reduced entries into the central area in male offspring (p < 0.05) at PND 50 with 50 mg/kg/day exposure. Reduced entries into the central area (p < 0.05) and time spent in the central area (p < 0.05) in female offspring at PND 50 with 10 mg/kg/day exposure. Increased number of closed arm entries (p < 0.05) and time spent in closed arms (p < 0.05) in male offspring at PND 50 with 200 mg/kg/day exposure. Increased time spent in closed arms in female offspring (p < 0.05) at PND 50 with 200 mg/kg/day exposure. Increased escape latency on training days 2 (p < 0.001) and 3 (p < 0.05) in male offspring at PND 50 with 200 mg/kg/day exposure. Reduced time spent in the target quadrant in male offspring during probe trial (p < 0.05) with 10 mg/kg/day and 50 mg/kg/day exposure.

Animal Model:	ISA Brown laying hens (female, ~21 weeks of age, average weight 1.65 kg)^[2]
Dosage:	43.6 mg/kg body weight/day; 65.5 mg/kg body weight/day
Administration:	p.o. via drinking water; daily; 7 days
Result:	Reached concentrations in yolk ranging from 257-5358 μg/kg and in egg white ranging from 778-4737 μg/kg during treatment at 43.6 mg/kg/day dose. Reached maximal concentrations of 5920 μg/kg in yolk and 4831 μg/kg in white on day 2 post-treatment at 43.6 mg/kg/day dose. Had elimination half-life of 4.58 days in yolk and 8.04 days in white at 43.6 mg/kg/day dose. Dropped below limit of detection (1.9 μg/kg) in yolk by day 16 post-treatment, and remained above limit of detection in white through day 37 post-treatment at 43.6 mg/kg/day dose. Fell concentrations below 100 μg/kg in yolk between days 11-13 post-treatment, and in white between days 19-22 post-treatment at 43.6 mg/kg/day dose. Reached concentrations in yolk ranging from 358-8101 μg/kg and in egg white ranging from 1025-6018 μg/kg during treatment at 65.5 mg/kg/day dose. Reached maximal concentrations of 9453 μg/kg in yolk and 6050 μg/kg in white on day 2 post-treatment at 65.5 mg/kg/day dose. Had elimination half-life of 5.37 days in yolk and 9.94 days in white at 65.5 mg/kg/day dose. Dropped below limit of detection (1.9 μg/kg) in yolk by day 19 post-treatment, and remained above limit of detection in white through day 37 post-treatment at 65.5 mg/kg/day dose. Fell concentrations below 100 μg/kg in yolk between days 11-13 post-treatment, and in white between days 19-22 post-treatment at 65.5 mg/kg/day dose. Observed significant differences in concentrations between yolk and white during post-treatment period (p ≤ 0.05): for 43.6 mg/kg/day dose, higher concentrations were measured in white on days 7, 10, 13, and 16; for 65.5 mg/kg/day dose, higher concentrations were measured in white on days 1-19 (except day 4).

Molecular Weight

302.29

Formula

C₁₁H₁₁N₄NaO₃S

CAS No.

38006-08-5

Appearance

Solid

Color

White to off-white

SMILES

COC1=NC=NC(=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 175 mg/mL (578.91 mM; Need ultrasonic)

DMSO : 100 mg/mL (330.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3081 mL	16.5404 mL	33.0808 mL
5 mM	0.6616 mL	3.3081 mL	6.6162 mL
10 mM	0.3308 mL	1.6540 mL	3.3081 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (248 KB) HNMR (114 KB) LCMS (227 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang Q, et al. Physiological and behavioral responses in offspring mice following maternal exposure to sulfamonomethoxine during pregnancy. Neurosci Lett. 2016;624:8-16.

[2]. Bilandžić N, et al. Distribution of sulfamonomethoxine and trimethoprim in egg yolk and white. Food Chem. 2015;178:32-37.

[3]. Huang DJ, et al. Toxicity of the veterinary sulfonamide antibiotic sulfamonomethoxine to five aquatic organisms. Environ Toxicol Pharmacol. 2014;38(3):874-880. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.3081 mL	16.5404 mL	33.0808 mL	82.7020 mL
	5 mM	0.6616 mL	3.3081 mL	6.6162 mL	16.5404 mL
	10 mM	0.3308 mL	1.6540 mL	3.3081 mL	8.2702 mL
	15 mM	0.2205 mL	1.1027 mL	2.2054 mL	5.5135 mL
	20 mM	0.1654 mL	0.8270 mL	1.6540 mL	4.1351 mL
	25 mM	0.1323 mL	0.6616 mL	1.3232 mL	3.3081 mL
	30 mM	0.1103 mL	0.5513 mL	1.1027 mL	2.7567 mL
	40 mM	0.0827 mL	0.4135 mL	0.8270 mL	2.0676 mL
	50 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.6540 mL
	60 mM	0.0551 mL	0.2757 mL	0.5513 mL	1.3784 mL
	80 mM	0.0414 mL	0.2068 mL	0.4135 mL	1.0338 mL
	100 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.8270 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.