Distribution of sulfamonomethoxine and trimethoprim in egg yolk and white

  • Food Chem. 2015 Jul 1:178:32-7. doi: 10.1016/j.foodchem.2015.01.076.
Nina Bilandžić  1 ,  Đurđica Božić  2 ,  Božica Solomun Kolanović  2 ,  Ivana Varenina  2 ,  Luka Cvetnić  3 ,  Željko Cvetnić  4
Affiliations
  • 1. Department of Veterinary Public Health, Laboratory for Residue Control, Croatian Veterinary Institute, Savska cesta 143, HR-10000 Zagreb, Croatia. Electronic address: [email protected].
  • 2. Department of Veterinary Public Health, Laboratory for Residue Control, Croatian Veterinary Institute, Savska cesta 143, HR-10000 Zagreb, Croatia.
  • 3. Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.
  • 4. General Department, Croatian Veterinary Institute, Savska cesta 143, HR-10000 Zagreb, Croatia.
PMID: 25704680 DOI: 10.1016/j.foodchem.2015.01.076
Abstract

The distribution of sulfamonomethoxine (SMM) and trimethoprim (TMP) in egg yolk and white was measured during and after administration of a SMM/TMP combination in laying hens in doses of 8 g l(-)(1) and 12 g l(-)(1) in drinking water for 7 days. The SMM concentration reached maximal levels on day 2 of the post-treatment period for both doses (μg kg(-)(1)): 5920 and 9453 in yolk; 4831 and 6050 in white, in doses 1 and 2, respectively. Significant differences in the SMM and TMP concentrations between yolk and white in post treatment period were found. SMM dropped below the LOD (1.9 μg kg(-1)) in yolk after day 16 and 19 for doses 1 and 2. TMP reached maximal levels on day 3 after drug administration for doses 1 and 2 (μg kg(-)(1)): 6521 and 7329 in yolk, 1370 and 1539 in white. TMP residues were measured above LOD (0.3 μg kg(-)(1)) in yolk for both doses on day 37 post-treatment.

Keywords
Egg; Elimination; LC–MS/MS; Laying hens; Sulfamonomethoxine; Trimethoprim; White; Yolk.
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