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Sesamin 

Cat. No.: HY-N0121 Purity: 99.89%
Handling Instructions

Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia.

For research use only. We do not sell to patients.

Sesamin Chemical Structure

Sesamin Chemical Structure

CAS No. : 607-80-7

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5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 85 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2].

IC50 & Target

delta 5 desaturase[1]

In Vitro

Pretreated with sesamin, Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated[1].

In Vivo

Sesamin (o.p.; 20 mg/kg/day) significantly reduces the infarct size by approximately 50% in male gerbils (60-85 g)[1].

Molecular Weight

354.35

Formula

C₂₀H₁₈O₆

CAS No.

607-80-7

SMILES

[H][[email protected]@]12[[email protected]@H](C3=CC=C(OCO4)C4=C3)OC[[email protected]]1([H])[[email protected]@H](C5=CC=C(OCO6)C6=C5)OC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (338.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8221 mL 14.1103 mL 28.2207 mL
5 mM 0.5644 mL 2.8221 mL 5.6441 mL
10 mM 0.2822 mL 1.4110 mL 2.8221 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (8.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (8.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SesaminOthersdeltadesaturasepolyunsaturatedfattyacidbiosynthesisneuroprotectioncerbralischemiaInhibitorinhibitorinhibit

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Product Name:
Sesamin
Cat. No.:
HY-N0121
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