607-80-7
607-80-7
Chemical Structure
Sesamin
- CAS. Nr.: 607-80-7
- Formula:C20H18O6
- Molecular Weight:354.35
IUPAC Name: (1S,3aR,4S,6aR)-1,4-bis(benzo[d][1,3]dioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan
InChIKey: PEYUIKBAABKQKQ-AFHBHXEDSA-N
SMILES: [H][C@@]12[C@@H](C3=CC=C(OCO4)C4=C3)OC[C@]1([H])[C@@H](C5=CC=C(OCO6)C6=C5)OC2
Biological Activity: Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Sesamin | 99.85% | Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia. | ||||||||||||||||||||
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Sesamin (Standard) | 98.72% | Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia. | ||||||||||||||||||||
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Sesamin-d8 | Sesamin-d8 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia. | |||||||||||||||||||||
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Sesamin-d4 | Sesamin-d4 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia. | |||||||||||||||||||||
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(-)-Sesamin | 99.17% | (-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. | ||||||||||||||||||||
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(-)-Asarinin | 99.97% | (-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a Ki of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects. | ||||||||||||||||||||
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Asarinin | 99.84% | Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb. | ||||||||||||||||||||
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DL-Asarinin | DL-Asarinin (compound 88) is a natural product that can be found in waste leaves of Cinnamomum camphora. | |||||||||||||||||||||
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Fargesin (Standard) | ≥98% | Fargesin (Standard) is the analytical standard of Fargesin. This product is intended for research and analytical applications. Fargesin is a bioactive neolignan isolated from magnolia plants, with antihypertensive and anti-inflammatory effects. | ||||||||||||||||||||
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Sesamolin (Standard) | ≥98% | Sesamolin (Standard) is the analytical standard of Sesamolin. This product is intended for research and analytical applications. Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesamolin potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. | ||||||||||||||||||||
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Sesaminol | Sesaminol is an orally active antioxidant. Sesaminol induces G1 phase arrest and inhibits cancer cell growth by binding to ANT2, inhibiting mTORC1, and promoting cyclin D1 degradation; it also activates Nrf2/NQO1, inhibits ROS- and neurotoxin-induced apoptosis (apoptosis), reduces α-synuclein (α-synuclein) and Aβ oligomerization/fibril formation, and promotes M2 microglial polarization. Sesaminol can be used in research on cancer, Parkinson's disease, obesity, Alzheimer's disease, colitis, cognitive decline, and liver diseases. | |||||||||||||||||||||
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Piperitol | Piperitol is a compound isolated from the Tibetan medicinal plant Lancea tibetica. | |||||||||||||||||||||
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Kobusin | 99.69% | Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel. | ||||||||||||||||||||
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(+)-Fargesin | (+)-Fargesin is a natural lignan. | |||||||||||||||||||||
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References
- [1]. Cheng FC, et al. Neuroprotective effects of sesamin and sesamolin on gerbil brain in cerebral ischemia. Int J Biomed Sci. 2006 Sep;2(3):284-8. [Content Brief]
- [2]. Shimizu S, et al. Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acidbiosynthesis. Lipids. 1991 Jul;26(7):512-6. [Content Brief]
