1. Membrane Transporter/Ion Channel
  2. CFTR
    Chloride Channel
  3. Kobusin

Kobusin 

Cat. No.: HY-N5101
Handling Instructions

Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel.

For research use only. We do not sell to patients.

Kobusin Chemical Structure

Kobusin Chemical Structure

CAS No. : 36150-23-9

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Description

Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2].

In Vitro

Kobusin could activate the function of CFTR and CaCCgie (CaCC expressed in gastrointestinal epithelial cells) chloride channels. Notably, Kobusin could inhibit the activities ANO1/CaCC chloride channel in ANO1/CaCC-expressing FRT cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In charcoal transit study, Kobusin mildly reduced gastrointestinal motility in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

370.40

Formula

C₂₁H₂₂O₆

CAS No.
SMILES

COC1=CC=C([[email protected]]2OC[[email protected]]3([H])[[email protected]@H](C4=CC=C(OCO5)C5=C4)OC[[email protected]@]32[H])C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

KobusinCFTRChloride ChannelCystic fibrosis transmembrane conductance regulatorCl− ChannelsbisepoxylignanCaCCgieANO1CaCCInhibitorinhibitorinhibit

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