Natural angiotensin II type 1 receptor inhibitors: Virtual screening and in vitro evaluation of beta-1,2,3,4,6-penta-O-galloyl-d-glucopyranose, icarrin, and sesamin for osteoarthritis therapy

  • Int J Biol Macromol. 2025 May;309(Pt 1):142184. doi: 10.1016/j.ijbiomac.2025.142184.
Bhavneet Kaur  1 ,  Harvinder Singh  2 ,  Gajendra Choudhary  3 ,  Ajay Prakash  3 ,  Bikash Medhi  3 ,  Debajyoti Chatterjee  4 ,  Uttam Chand Saini  5 ,  Jyotdeep Kaur  1 ,  Indu Verma  1 ,  Sadhna Sharma  6
Affiliations
  • 1. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • 2. Department of Translational and Regenerative Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • 3. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • 4. Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • 5. Department of Orthopaedics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
  • 6. Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address: [email protected].
PMID: 40147655 DOI: 10.1016/j.ijbiomac.2025.142184
Keywords
Angiotensin II type 1 receptor; Knee osteoarthritis; Molecular docking.
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