1. Membrane Transporter/Ion Channel
  2. Chloride Channel
  3. Niflumic acid

Niflumic acid 

Cat. No.: HY-B0493 Purity: 99.86%
Handling Instructions

Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

For research use only. We do not sell to patients.

Niflumic acid Chemical Structure

Niflumic acid Chemical Structure

CAS No. : 4394-00-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
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Description

Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. Target: Others niflumic acid, an inhibitor of calcium-activated chloride currents. Niflumic acid does not block directly calcium channels or activate potassium channels. Niflumic acid selectively reduces a component of noradrenaline- and 5-HT-induced pressor responses by inhibiting a mechanism which leads to the opening of voltage-gated calcium channels [1]. Niflumic acid molecule is completely buried in the substrate-binding hydrophobic channel. The conformations of the binding site in PLA(2) as well as that of niflumic acid are not altered upon binding [2]. Niflumic acid (NFA) produces biphasic behavior on human CLC-K channels that suggests the presence of two functionally different binding sites: an activating site and a blocking site [3].

Molecular Weight

282.22

Formula

C₁₃H₉F₃N₂O₂

CAS No.

4394-00-7

SMILES

O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (354.33 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5433 mL 17.7167 mL 35.4333 mL
5 mM 0.7087 mL 3.5433 mL 7.0867 mL
10 mM 0.3543 mL 1.7717 mL 3.5433 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Niflumic acidChloride ChannelCl− ChannelsInhibitorinhibitorinhibit

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Niflumic acid
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HY-B0493
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